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Diabetes mellitus and head and neck cancer

Grant number: 13/21702-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2014
Effective date (End): February 29, 2016
Field of knowledge:Health Sciences - Collective Health
Principal Investigator:Victor Wünsch Filho
Grantee:Rejane Augusta de Oliveira Figueiredo
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):14/18893-4 - Diabetes mellitus and head and neck cancer, BE.EP.DR

Abstract

Head and neck cancer (HNC) includes tumors of the mouth, oropharynx, hypopharynx and larynx. The use of tobacco and alcohol are the main risk factors associated with HNC, however other risk factors have also been considered such as diet, occupational agents, oral hygiene and HPV infection. Several studies have found that patients with Diabetes Mellitus (DM) have excess of risk and worse prognosis of some cancers such as liver, pancreas, colorectal, breast and others. Recently, it has been suggested the association of DM and HNC. However, few studies have been conducted on this topic. Major studies have only considered the presence of DM mentioned by the respondent. There is evidence that the DM self-reported prevalence reflects approximately 46% less than the actual detected by laboratory tests. In the present study, in addition to self-reported disease, DM will be measured by examining glycated hemoglobin (A1C). Also, information will be obtained from the medical records of patients to increase the reliability of the occurrence of DM. Objective: evaluate the association of diabetes mellitus and head and neck cancer. Material and methods: this case-control study is being conducted at five clinical centers in the State of São Paulo. By the end of 2014, a sample of 1400 cases and 1000 controls from the participating hospitals is estimated to be obtained. The cases are individuals diagnosed with HNC, confirmed by histopathology. Controls can be hospital or visitors of patients, matched to the cases by frequency of sex, age and area of residence. Expected results: we expected with this study to achieve sufficient sample size to examine the association of DM and HNC with adjustments for confounding variables. (AU)

Articles published in Agência FAPESP about the scholarship:
Antidiabetic drug is tested against head and neck cancer 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA FIGUEIREDO, REJANE AUGUSTA; WEIDERPASS, ELISABETE; TAJARA, ELOIZA HELENA; STROM, PETER; CARVALHO, ANDRE LOPES; DE CARVALHO, MARCOS BRASILINO; KANDA, JOSSI LEDO; MOYSES, RAQUEL AJUB; WUNSCH-FILHO, VICTOR. Diabetes mellitus, metformin and head and neck cancer. Oral Oncology, v. 61, p. 47-54, OCT 2016. Web of Science Citations: 5.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
Diabetes mellitus and head and neck cancer. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública São Paulo.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.