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Chemical-pharmaceutical analysis of Cefepime hydrochloride in lyophilized powder for injectable solution

Grant number: 13/20017-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2014
Effective date (End): May 31, 2017
Field of knowledge:Health Sciences - Pharmacy - Medicines Analysis and Control
Principal Investigator:Hérida Regina Nunes Salgado
Grantee:Danilo Fernando Rodrigues
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):15/01551-6 - Identification of degradation products of cefepime hydrochloride by LC-HRMS, BE.EP.DR


The emergence of resistant microorganisms to a large number of clinically approved antimicrobials has been increasingly used, which limits the options for the treatment of bacterial infections. As a strategy, drugs with high antimicrobial activities are in evidence. Stands out a class of antimicrobial, the cephalosporins, having as fourth generation cefepime a semi-synthetic product which has activity against various Gram-positive bacteria (e.g. oxacillin resistant Staphylococcus aureus) and Gram-negative (e.g. Pseudomonas aeruginosa) aerobic. Its mechanism of action is similar to other ²-lactams, that mean, inhibits bacterial cell wall synthesis by binding to one or more penicillin binding proteins (Penicillin-Binding Proteins - PBPs). In this context, innovative research involving analytical methods present fundamental importance and it is highly relevant to optimize its analysis in routine pharmaceutical industry and ensure quality of product already marketed. The project aims to develop and validate innovative analytical methods for analysis of cefepime in pharmaceutical formulation by spectrophotometry in the regions of ultraviolet, infrared and visible, high performance liquid chromatography and microbiological assay, as well as to conduct stability studies that will be held at York University - Toronto, Canada. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES, DANILO F.; SALGADO, HERIDA R. N. Development and Validation of an Leo-Friendly and Low-Cost Method for the Quantification of Cefepime Hydrochloride in Powder for Injectable Solution Using Infrared (IR) Spectroscopy. CURRENT ANALYTICAL CHEMISTRY, v. 16, n. 4, p. 456-464, 2020. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
RODRIGUES, Danilo Fernando. Análise químico-farmacêutica de cloridrato de cefepima em pó liofilizado para solução injetável. 2017. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas, Araraquara.

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