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Bioinformatics and modelling

Grant number: 13/24212-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2014
Effective date (End): April 10, 2018
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Hugo Aguirre Armelin
Grantee:Vincent Olivier Jean-Marie Noel
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling, AP.CEPID


Build computational models of the cell cycle control, mitogen activation and inflammationrelated pathways using differential equations and stochastic models. It is expected that the models fit and predict well the experimental (wet lab) and literature data. The fellowship candidates will have solid knowledge in computer science or probability and statistics and must be eager to learn the molecular biology and biochemistry involved. Phase 1 (years 1-2): Build simple models. Phase 2 (years 3-4): Connect the models. Phase 3 (year 5): Enhance the models.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DIAS, MATHEUS H.; FONSECA, CECILIA S.; ZEIDLER, JULIANNA D.; ALBUQUERQUE, LAYRA L.; DA SILVA, MARCELO S.; CARARO-LOPES, EDUARDO; REIS, MARCELO S.; NOEL, VINCENT; DOS SANTOS, EDMILSON O.; PRIOR, IAN A.; ARMELIN, HUGO A. Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors. MOLECULAR ONCOLOGY, v. 13, n. 2, p. 290-306, FEB 2019. Web of Science Citations: 0.

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