Effect of Bradykinin on bone resorption induced by LPS in alive

• Grant number: 13/20600-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2014
• End date: January 31, 2015
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Pedro Paulo Chaves de Souza
• Grantee: Larissa Gaillardetz Corbani
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Besides the classical action of the kallikrein-kinin system (KKS) in the modulation of the vascular tonus, this system is also involved in different pathologies, some of them being inflammatory in nature. Inflammatory processes in the vicinity of the skeleton generally leads to bone loss, and in vitro models demonstrate that kinins may participate of inflammatory bone resorption by activating the B1 and B2 kinin receptors. In contrast with these findings, some in vivo studies demonstrate an inhibitory role of the KKS on bone resorption and osteoclast differentiation. Therefore, the aim of the present project is to analyze the role of kinins on LPS inducedbone resorption in vivo. Calvarial bones from animals exposed tosupracalvarial injections of bradykinin alone or in combination with LPS will be dissected and analyzed histologically and by microcomputed tomography.