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Study of proteins associated with meat quality phenotypes in Nelore cattle

Grant number: 13/21017-9
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): February 01, 2014
Effective date (End): September 30, 2017
Field of knowledge:Agronomical Sciences - Animal Husbandry
Principal Investigator:Luiz Lehmann Coutinho
Grantee:Mirele Daiana Poleti
Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Associated research grant:12/23638-8 - Molecular basis of meat quality in Nelore beef cattle, AP.TEM

Abstract

Brazil is one of the leading producers and exporters of beef and its competitive advantage is mainly attributed to the cost of production of Brazilian beef, which is one of the lowest in the world. To increase its importance in the market, one must adapt its meat production to the standards established by external market. Among the quality attributes, tenderness, amount and composition of intramuscular fat (IMF) can influence the sensory characteristics and nutritional value of beef. Selection for meat quality has not been effective in breeding programs of beef cattle in Brazil. Sequencing, genotyping and expression analysis technologies on a genome-scale have contributed to the knowledge of the genetic basis of variation and for the earlier selection in cattle. A previous project entitled "Genetic Strategies for quality beef production" produced 796 steers, offspring of 34 sires representing the diversity of Nelore. The steers were evaluated for feed efficiency and meat quality and both sires and offspring had their genotypes analyzed in the Illumina SNP BovineHD chip. This project identified genomic regions associated with production characteristics and meat quality. The present project aims to achieve a better understanding of the genetic mechanisms involved in variation in quantitative traits highlighted by the association analysis. Therefore, it is proposed to complement the analysis of genome wide association to include new phenotypes, expanding the functional analysis of the genome (RNA, microRNA and proteins), assess the significance of CNVs and train human resources in the areas of bioinformatics and genomics. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAPPELER, BERNA I. G.; REGITANO, LUCIANA C. A.; POLETI, MIRELE D.; CESAR, ALINE S. M.; MOREIRA, GABRIEL C. M.; GASPARIN, GUSTAVO; COUTINHO, LUIZ L. MiRNAs differentially expressed in skeletal muscle of animals with divergent estimated breeding values for beef tenderness. BMC MOLECULAR BIOLOGY, v. 20, JAN 3 2019. Web of Science Citations: 0.
POLETI, MIRELE D.; REGITANO, LUCIANA C. A.; SOUZA, GUSTAVO H. M. F.; CESAR, ALINE S. M.; SIMAS, ROSINEIDE C.; SILVA-VIGNATO, BARBARA; OLIVEIRA, GABRIELLA B.; ANDRADE, SONIA C. S.; CAMERON, LUIZ C.; COUTINHO, LUIZ L. Data from proteomic analysis of bovine Longissimus dorsi muscle associated with intramuscular fat content. DATA IN BRIEF, v. 19, p. 1314-1317, AUG 2018. Web of Science Citations: 0.
POLETI, MIRELE D.; REGITANO, LUCIANA C. A.; SOUZA, GUSTAVO H. M. F.; CESAR, ALINE S. M.; SIMAS, ROSINEIDE C.; SILVA-VIGNATO, BARBARA; OLIVEIRA, GABRIELLA B.; ANDRADE, SONIA C. S.; CAMERON, LUIZ C.; COUTINHO, LUIZ L. Longissimus dorsi muscle label-free quantitative proteomic reveals biological mechanisms associated with intramuscular fat deposition. JOURNAL OF PROTEOMICS, v. 179, p. 30-41, MAY 15 2018. Web of Science Citations: 5.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.