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Biofunctional vitreous coatings for medical and dental implants

Grant number: 12/17646-8
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2014
Effective date (End): February 28, 2017
Field of knowledge:Engineering - Materials and Metallurgical Engineering
Principal Investigator:Sonia Regina Homem de Mello Castanho
Grantee:Felipe Antunes Santos
Host Institution: Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil


The project proposes to develop a vitreous material covering a metallic surface of a biomaterial. Currently the most metallic biomaterials used in medical and dental applications are titanium and its alloys, stainless steel and cobalt-chromium alloys. Even when the materials provide good osseointegration characteristics (biocompatible) many implants are subject to infections during and after surgery. Actions aiming to simplify and protect these surgeries have been the object of concentrated efforts of both, scientific research and the productive sector. Develop materials capable of accelerating osseointegration mechanisms constitutes an important contribution. In addition, the possibility to add functions to protect bacterial infection (materials with biocide action) for these procedures opens a new horizon for development of multifunctional materials focused on implantology. This proposal seeks the multifunctional action of the coating material, made from glass matrix composites, showing positive response to the both functions, biocompatibility and biocide comportment. Applying the thermodynamic concepts for planning compositions, will be studied glasses of CaO- Na2O- SiO2 - M system. The possibly metals to be tested are Ag, Cu, Nb, W, Ta or Zr, in nanoparticles form, which have demonstrated good biocompatibility results. The scientific and technological challenge of this proposal is to integrate, effectively, dissimilar functions, as a biocide action and osseointegration, in the same material, contributing in the recovery process of patients.Thus it will be important to compare compositions, studying the various performances of metals (nanoparticles) in relation to the bioactivities such as cytotoxicity and dissolution rate in the body environment, as well as in relation to the physical behavior, as mechanical properties, wettability and thermal expansion of the materials in contact (glass / substrate). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, FELIPE A.; SILVA, ANTONIO C.; SANTOS, CLAUDINEI; SIMBA, BRUNO G.; BARTOLOME, JOSE F.; DURAN, TERESA; FERNANDEZ-GARCIA, ELISA; ROGERO, SIZUE O.; MELLO-CASTANHO, SONIA R. H.. Biocide glass based on Nb2O5-SiO-CaO-Na2O system. Materials Letters, v. 183, p. 277-280, . (12/17646-8)

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