Arterial stiffness and vascular resistance in patients with metabolic syndrome: effect of hypocaloric diet associated with exercise training

• Grant number: 13/15323-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2014
• End date: November 30, 2015
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Ivani Credidio Trombetta
• Grantee: Sara Rodrigues
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

SummaryMetabolic syndrome (MetS) is characterized by overlapping of risk factors such as dyslipidemia, hypertension, insulin resistance and visceral obesity. Independently, these factors cause morphological and functional changes in the vascular system, which directly relate to increased risk of cardiovascular events and death. This study aims to: 1) identify any impairment on central and peripheral vascular morphology/function in subjects with MetS; 2) investigate whether there is a relationship between the injury in these two beds, and 3) determine the effect of weight loss and increased physical capacity obtained by hypocaloric diet and exercise training specifically in the arterial stiffness, intima-media thickness, peripheral vascular resistance and blood pressure. Patients with MetS (according to ATP-III) will be divided into 2 groups: control group for intervention (MetS/C n=14), with only clinical follow-up, and intervention group, (MetS/TF+D +, where: D=decrease 500 Kcal/day; and TF=3 times/week, 50-70% VO2peak, n=14) which will be submitted to diet and physical training for 4 months. A healthy control group matched for age and gender will also be involved in the study (C=10). Will be assessed: body composition (bioelectrical impedance), clinical profile and metabolic fitness (ergospirometry), muscle blood flow (venous oclusion plethysmography), blood pressure (oscillometric), heart rate (ECG), oxygen saturation (pulse oximeter), respiratory rate (piezoeletric), arterial stiffness (pulse wave velocity, PWV) and 24h blood pressure (ambulatory blood pressure measurement, ABPM).

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CEPEDA, FELIPE X.; VIRMONDES, LESLIE; RODRIGUES, SARA; DUTRA-MARQUES, AKOTHIRENE C. B.; TOSCHI-DIAS, EDGAR; FERREIRA-CAMARGO, FERNANDA C.; HUSSID, MARIA FERNANDA; RONDON, MARIA URBANA P. B.; ALVES, MARIA JANIEIRE N. N.; TROMBETTA, IVANI C.. Identifying the risk of obstructive sleep apnea in metabolic syndrome patients: Diagnostic accuracy of the Berlin Questionnaire. PLoS One, v. 14, n. 5, MAY 21 2019. (15/03274-0, 16/16831-7, 11/17533-6, 13/15323-0, 13/07651-7)

RODRIGUES, SARA; CEPEDA, FELIPE X.; TOSCHI-DIAS, EDGAR; DUTRA-MARQUES, AKOTHIRENE C. B.; CARVALHO, JEFFERSON C.; COSTA-HONG, VALERIA; ALVES, MARIA JANIEIRE N. N.; RONDON, MARIA URBANA P. B.; BORTOLOTTO, LUIZ A.; TROMBETTA, IVANI C.. The role of increased glucose on neurovascular dysfunction in patients with the metabolic syndrome. JOURNAL OF CLINICAL HYPERTENSION, v. 19, n. 9, p. 840-847, SEP 2017. (11/17533-6, 15/03274-0, 13/15323-0, 13/07651-7)

LOPES-VICENTE, WANDA R. P.; RODRIGUES, SARA; CEPEDA, FELIPE X.; JORDAO, CAMILA PAIXAO; COSTA-HONG, VALERIA; DUTRA-MARQUES, AKOTHIRENE C. B.; CARVALHO, JEFFERSON C.; ALVES, MARIA JANIEIRE N. N.; BORTOLOTTO, LUIZ A.; TROMBETTA, IVANI C.. Arterial stiffness and its association with clustering of metabolic syndrome risk factors. DIABETOLOGY & METABOLIC SYNDROME, v. 9, OCT 25 2017. (11/17533-6, 16/16831-7, 13/15323-0)

CARVALHO, JEFFERSON CABRAL; CEPEDA, FELIPE XEREZ; RODRIGUES, SARA; BRISOLLA DUTRA-MARQUES, AKOTHIRENE CRISTHINA; TOSCHI-DIAS, EDGAR; PINTO BRANDAO RONDON, MARIA URBANA; NUNES ALVES, MARIA-JANIEIRE NAZARE; FONSECA WANDERLEY BRAGA, ANA MARIA; LORENZI-FILHO, GERALD; TROMBETTA, IVANI CREDIDIO. Oxygen uptake efficiency slope in patients with metabolic syndrome and obstructive sleep apnea. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (13/07651-7, 15/03274-0, 11/17533-6, 13/15323-0)

CEPEDA, FELIPE XEREZ; RODRIGUES, SARA; DUTRA-MARQUES, AKOTHIRENE C. B.; CARVALHO, JEFFERSON CABRAL; TOSCHI-DIAS, EDGAR; JORDAO, CAMILA PAIXAO; RONDON, MARIA URBANA; ALVES, MARIA JANIEIRE N. N.; LORENZI-FILHO, GERALDO; TROMBETTA, IVANI CREDIDIO. Obstructive sleep apnea impairs insulin resistance in metabolic syndrome patients with normal levels of glucose. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (13/07651-7, 15/03274-0, 11/17533-6, 13/15323-0)

VICENTE, WANDA RAFAELA; RODRIGUES, SARA; DUTRA-MARQUES, AKOTHIRENE C. B.; CARVALHO, JEFFERSON C.; JORDAO, CAMILA P.; TOSCHI-DIAS, EDGAR; HUSSID, MARIA FERNANDA; COSTA-HONG, VALERIA; BORTOLOTTO, LUIZ A.; CEPEDA, FELIPE X.; et al. Clustering and combining pattern of metabolic syndrome risk factors and its association with arterial stiffness. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (13/07651-7, 15/03274-0, 11/17533-6, 13/15323-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

RODRIGUES, Sara. Arterial stiffness and peripheral vascular resistance in newly diagnosed metabolic syndrome patients. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.