|Support type:||Scholarships in Brazil - Master|
|Effective date (Start):||March 01, 2014|
|Effective date (End):||August 31, 2015|
|Field of knowledge:||Health Sciences - Pharmacy - Pharmaceutical Technology|
|Principal Investigator:||Maria Vitória Lopes Badra Bentley|
|Grantee:||Clemilton Pereira da Cunha|
|Home Institution:||Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil|
Psychosis is a serious mental disorder with a profound impact on social, professional and high risk of suicide. Risperidone is an atypical antipsychotic drug available in various dosage forms. However, poor adherence is the main barrier to medical therapy instituted . Systems for controlled release of drugs offer several advantages over conventional therapies ( maintenance of plasma concentration, improved adherence to treatment , etc.). This project aims to develop a microemulsion system for transdermal delivery of risperidone , its physicochemical characterization and evaluation in vitro release profile and permeation of the drug compared to the models of biomembranes and synthetic membrane. The proposed method consists in obtaining the microemulsions by constructing phase diagrams. Development and validation of HPLC analytical method for quantification of risperidone in the different experimental stages . Characterization of the obtained formulations by measuring the pH , viscosity and rheology, polarized light microscopy, determination of particle size and IPD, zeta potential and conductivity. In vitro release studies with synthetic membranes. Studies of skin permeation and retention in vitro pig ear skin. The results will be analyzed by statistical tests by ANOVA followed by comparison of variables by t -test.