Characterization of the inflammatory profile in mice knockouts for TRL4 during the development of the Syndrome of Cachexia

• Grant number: 14/00922-8
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): March 01, 2014
• Effective date (End): March 31, 2015
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Miguel Luiz Batista Junior
• Grantee: Pamela Viegas Knobl
• Host Institution: Pró-Reitoria de Pesquisa, Pós-Graduação e Extensão. Universidade de Mogi das Cruzes (UMC). Mogi das Cruzes , SP, Brazil

Abstract

Cachexia, by his character syndrome affects multiple systems in the body compartments and bearer of neoplasia, breaking the steady-state characteristic of the systems, leading to metabolic chaos. The current vision syndrome or as an inflammatory process, either as a physiological imbalance so deep as to be proposed as a causative agent and not a consequence of the appearance of tumors, which demonstrate the inadequacy of the information obtained up to the present. The severe loss of White Adipose Tissue (WAT) is a major "markers" clinical cancer Cachexia. This process seems to be the result of a series of metabolic and inflammatory factors produced due to both by the host and the tumor itself. Since inflammation plays a prominent role in the etiology of the syndrome, several research groups have attempted to identify the tissues and systems that either are subject to inflammation, or are sources of systemic inflammatory mediators. However, little has been yet known about the increased leukocyte infiltration in this tissue during the development of the syndrome. Thus, we intend to analyze the changes in which the inflammatory process is acting in adipose tissue during Cachexia Syndrome. (AU)