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Impact of sleep restriction and deprivation on rats skin ageing

Grant number: 14/00923-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2014
Effective date (End): December 31, 2014
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Monica Levy Andersen
Grantee:Rachel Gimenes Rodrigues Albuquerque
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Skin ageing is a physiological process characterized by extracellular matrix reduction due to alterations on collagen synthesis, metalloproteases activity, hydration and vascularization of skin. Thus, skin aged is more susceptible to infections, trauma and impaired healing. Some factors are able to modulate these changes on skin, specially stress. The glucocorticoids generated by the stress response can affect skin thickness and synthesis of components. However, the control of these hormones depends on sleep. In today's society, lack of sleep is a frequent problem because of socio-economic and cultural pressures. Still, sleep plays an important role modulating the immune system, which can affect skin composition. Therefore, this project aims to investigate the effect of sleep time reduction and the recovery on skin ageing of rats. For this, 73 male Wistar rats will be distributed in 7 groups: Young Control (CTRL-Y), Middle-aged Control (CTRL-MA), Aged Control (CTRL-A), Young Paradoxical Sleep Deprivation (Y-PSD), Young Sleep Restriction (Y-SR), Young Paradoxical Sleep Deprivation followed by Rebound (Y-PSD-R) and Young Sleep Restriction followed by Rebound (Y-SR-R). Animals under PSD condition will be subjected to 96 hours of paradoxical sleep deprivation, animals from SR group will be subjected to sleep restriction (20 hours/day) during 21 days. At the end, all the animals will be euthanized for blood collection (corticosterone and circulating cytokines dosage) and skin fragments (histological analysis). We expect with this project to evaluate if reduction of sleep time accelerates skin ageing on young rats. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALBUQUERQUE, RACHEL GIMENES; OKAZAKI, KEITY MEY; HIROTSU, CAMILA; TOMIMORI, JANE; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Sleep, Hansen's disease and the immune system - A not so harmonic triad. Medical Hypotheses, v. 84, n. 5, p. 456-459, . (14/00923-4, 12/21794-2, 14/15259-2)
ALBUQUERQUE, RACHEL GIMENES; DIAS DA ROCHA, MARCO ALEXANDRE; HIROTSU, CAMILA; HACHUL, HELENA; BAGATIN, EDILEIA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. A randomized comparative trial of a combined oral contraceptive and azelaic acid to assess their effect on sleep quality in adult female acne patients. ARCHIVES OF DERMATOLOGICAL RESEARCH, v. 307, n. 10, p. 905-915, . (12/21794-2, 14/00923-4, 14/15259-2)
HIROTSU, CAMILA; NOGUEIRA, HELOISA; ALBUQUERQUE, RACHEL G.; TOMIMORI, JANE; TUFIK, SERGIO; ANDERSEN, MONICA L.. The bidirectional interactions between psoriasis and obstructive sleep apnea. INTERNATIONAL JOURNAL OF DERMATOLOGY, v. 54, n. 12, p. 1352-1358, . (12/21794-2, 14/00923-4, 14/15259-2)

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