Chemical documentation of species from Casearia genus (Salicaceae) of ecological, economical and medicinal relevance

• Grant number: 14/02738-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): April 01, 2014
• Effective date (End): December 31, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Alberto Jose Cavalheiro
• Grantee: Naira Buzzo Anhesine
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated research grant: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery, AP.CEPID

Abstract

The Casearia genus (Salicaceae) is well known because of the medicinal use of its species. Among them, a noteworthy one is the C. sylvestris specie because it already has studies concerning its antiproliferative and/or cytotoxic activity in tumor cells. Furthermore, this specie is popularly used against snake bites, in gastric ulcers treatment and as anti-inflammatory. As well as this, there are other species from this same genus which have been poorly studied, such as the following species: C. grandiflora, C. javitensis, C. arborea, C. lasiophylla and C. ulmifolia. However, several biological activities have been reported for them. In this context, the aim of this project, besides of contributing to the Casearia genus studies, is to study those five species through the analysis and documentation of their leaves' chemical composition, as well as identify new second metabolites in this genus aiming the bioprospection of substances with medicinal and economical potential and finally promote the systematic study of some biological activities.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BUENO, PAULA CAROLINA PIRES; SALOME ABARCA, LUIS FRANCISCO; ANHESINE, NAIRA BUZZO; GIFFONI, MAIRA SILVA; PEREIRA, FABIOLA MANHAS VERBI; TORRES, ROSELI BUZANELI; DE SOUSA, RAYRAN WALTER RAMOS; FERREIRA, PAULO MICHEL PINHEIRO; PESSOA, CLAUDIA; CAVALHEIRO, ALBERTO JOSE. Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes. Planta Medica, v. 87, n. 01/02, DEC 2020. (16/20295-3, 12/21921-4, 11/21440-3, 19/01102-8, 14/50945-4, 14/02738-0, 18/18212-8, 13/07600-3)

ANHESINE, NAIRA BUZZO; PIRES BUENO, PAULA CAROLINA; TORRES, ROSELI BUZANELLI; LOPES, NORBERTO PEPORINE; CAVALHEIRO, ALBERTO JOSE. Non-polar and polar chemical profiling of six Casearia species (Salicaceae). Biochemical Systematics and Ecology, v. 87, DEC 2019. (11/21440-3, 13/07600-3, 14/02738-0)