Advanced search
Start date

Evaluation of central mechanisms in the renorenal reflex and the role of afferent renal nerves in renovascular hypertension

Grant number: 13/23741-6
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2014
Effective date (End): December 31, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Cassia Marta de Toledo Bergamaschi
Grantee:Erika Emy Nishi
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Studies have shown the strong neurogenic component in the development of arterial hypertension (AH) in humans and experimental models. Renal denervation in patients with resistant AH is an effective strategy to control blood pressure (BP) which has been related to the interruption of afferent renal nerves. However, the mechanisms related to this response remain to be elucidated. Our previous studies showed that the denervation of ischemic kidney significantly reduced BP (12%) and lead to downregulation of AT1 receptor within the rostral ventrolateral medulla, independent of plasma renin activity or BP reduction in an angiotensin II-dependent model of AH - 2 kidney, 1 clip (2K1C). These data suggest that afferent renal nerves might produce changes in the central nervous system and contribute to the increase of BP. Thus, the present project proposes the evaluation of afferent renal nerves effects in neuronal circuitry. For that, the neurochemistry of activated neurons following electrical stimulation of afferent renal nerve will be characterized in normotensive rats and, then, the central mechanisms of renorenal reflex will be evaluated physiologically in the main regions of cardiovascular processing and control. Finally, the role of afferent renal nerves in the changes of neuronal circuitry will be assessed in the renovascular hypertension. These studies will contribute to the understanding of central mechanisms associated to the antihypertensive effect of renal denervation in humans and animal models.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZAMBRANO, I, LYSIEN; PONTES, ROBERTO B.; GARCIA, MICHELLE L.; NISHI, ERIKA E.; NOGUEIRA, FERNANDO N.; HIGA, ELISA M. S.; CESPEDES, JULIANA G.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.. Pattern of sympathetic vasomotor activity in a model of hypertension induced by nitric oxide synthase blockade. PHYSIOLOGICAL REPORTS, v. 7, n. 14, . (18/02671-3, 13/22522-9, 13/23741-6)
MILANEZ, MAYCON I. O.; NISHI, ERIKA E.; SATO, ALEX Y. S.; FUTURO NETO, HENRIQUE A.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.. Control of renal sympathetic nerve activity by neurotransmitters in the spinal cord in Goldblatt hypertension. Brain Research, v. 1698, p. 43-53, . (13/13332-1, 13/23741-6)
LINCEVICIUS, GISELE S.; SHIMOURA, CAROLINE G.; NISHI, ERIKA E.; OLIVEIRA, TALES; CESPEDES, JULIANA G.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.. Differential effects of renal denervation on arterial baroreceptor function in Goldblatt hypertension model. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 208, p. 43-50, . (13/13332-1, 13/23741-6)
NISHI, ERIKA E.; MARTINS, BEATRIZ S.; MILANEZ, MAYCON I. O.; LOPES, NATHALIA R.; DE MELO, JR., JOSE F.; PONTES, ROBERTO B.; GIRARDI, ADRIANA C.; CAMPOS, RUY R.; BERGAMASCHI, CASSIA T.. Stimulation of renal afferent fibers leads to activation of catecholaminergic and non-catecholaminergic neurons in the medulla oblongata. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 204, p. 48-56, . (15/23858-6, 13/23741-6, 13/22522-9, 15/23809-5)
VEIGA, GLAUCIA L.; NISHI, ERIKA E.; ESTRELA, HEDER F.; LINCEVICIUS, GISELE S.; GOMES, GUIOMAR N.; SIMOES SATO, ALEX Y.; CAMPOS, RUY R.; BERGAMASCHI, CASSIA T.. Total renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney disease. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 204, p. 81-87, . (13/23741-6, 13/22522-9)
VEIGA, AMANDA C.; MILANEZ, MAYCON I. O.; FERREIRA, GIOVANNA R.; LOPES, NATHALIA R.; SANTOS, CAMILA P.; DE ANGELIS, KATIA; GARCIA, MICHELLE L.; OYAMA, LILA M.; GOMES, GUIOMAR N.; NOGUEIRA, FERNANDO N.; et al. Selective afferent renal denervation mitigates renal and splanchnic sympathetic nerve overactivity and renal function in chronic kidney disease-induced hypertension. Journal of Hypertension, v. 38, n. 4, p. 765-773, . (18/02671-3, 13/23741-6, 17/03905-5)
NISHI, ERIKA E.; ALMEIDA, VITOR R.; AMARAL, FERNANDA G.; SIMON, KARIN A.; FUTURO-NETO, HENRIQUE A.; PONTES, ROBERTO B.; CESPEDES, JULIANA G.; CAMPOS, RUY R.; BERGAMASCHI, CASSIA T.. Melatonin attenuates renal sympathetic overactivity and reactive oxygen species in the brain in neurogenic hypertension. HYPERTENSION RESEARCH, v. 42, n. 11, p. 1683-1691, . (10/09003-4, 13/23741-6, 13/22522-9)
CAMPOS, RUY R.; OLIVEIRA-SALES, ELIZABETH BARBOSA; NISHI, ERIKA E.; PATON, JULIAN F. R.; BERGAMASCHI, CASSIA T.. Mechanisms of renal sympathetic activation in renovascular hypertension. Experimental Physiology, v. 100, n. 5, p. 496-501, . (13/23741-6)

Please report errors in scientific publications list by writing to: