Studies have shown the strong neurogenic component in the development of arterial hypertension (AH) in humans and experimental models. Renal denervation in patients with resistant AH is an effective strategy to control blood pressure (BP) which has been related to the interruption of afferent renal nerves. However, the mechanisms related to this response remain to be elucidated. Our previous studies showed that the denervation of ischemic kidney significantly reduced BP (12%) and lead to downregulation of AT1 receptor within the rostral ventrolateral medulla, independent of plasma renin activity or BP reduction in an angiotensin II-dependent model of AH - 2 kidney, 1 clip (2K1C). These data suggest that afferent renal nerves might produce changes in the central nervous system and contribute to the increase of BP. Thus, the present project proposes the evaluation of afferent renal nerves effects in neuronal circuitry. For that, the neurochemistry of activated neurons following electrical stimulation of afferent renal nerve will be characterized in normotensive rats and, then, the central mechanisms of renorenal reflex will be evaluated physiologically in the main regions of cardiovascular processing and control. Finally, the role of afferent renal nerves in the changes of neuronal circuitry will be assessed in the renovascular hypertension. These studies will contribute to the understanding of central mechanisms associated to the antihypertensive effect of renal denervation in humans and animal models.
News published in Agência FAPESP Newsletter about the scholarship: