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Importance of genes fliC and motB of Salmonella enterica subsp. enterica serovar Enteritidis in intestinal colonization and systemic invasion in Gallus gallus domesticus

Grant number: 14/02014-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2014
Effective date (End): February 29, 2016
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Angelo Berchieri Junior
Grantee:Fernanda de Oliveira Barbosa
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


Salmonella spp. is one of the microorganisms of greatest impact on the poultry industry due to economic losses, as well as public health importance. Salmonella Enteritidis does not have a specific host and may cause disease in humans and birds. The ability of SE to colonize the enteric tract and invade their hosts are key factors for stablishing salmonellosis. The flagellum has been thought as an important structure for the pathogenicity of SE. Among its functions are to assist in intestinal colonization and stimulate innate and adaptive immune system. Although there are studies evaluating the role of the flagella in intestinal colonization and systemic invasion by SE, their results are controversial and require further investigation. The present study aims at evaluating the importance of the flagellum and motility of SE for intestinal colonization and systemic invasion in comercial layers. In order to investigate this subject, two SE mutante strains will be constructed. The first mutant will have a deletion in fliC gene (responsible for flagellin, the main component of the flagellar filament). The second mutant, although able to synthesize flagella, will have impaired motility due to inactivation of motB gene. Mutants together with the wild type SE will be inoculated in birds for pathogenesis evaluation.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARBOSA, FERNANDA DE OLIVEIRA; DE FREITAS NETO, OLIVEIRO CAETANO; ALVES BATISTA, DIEGO FELIPE; DE ALMEIDA, ADRIANA MARIA; RUBIO, MARCELA DA SILVA; RODRIGUES ALVES, LUCAS BOCCHINI; VASCONCELOS, ROSEMEIRE DE OLIVEIRA; BARROW, PAUL ANDREW; BERCHIERI JUNIOR, ANGELO. Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken. Brazilian Journal of Microbiology, v. 48, n. 4, p. 754-759, . (13/26127-7, 14/02014-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BARBOSA, Fernanda de Oliveira. Importance of genes fliC and motB OF Salmonella enterica subsp. enterica serovar Enteritidis in intestinal colonization and systemic invasion in birds (Gallus gallus domesticus). 2016. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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