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Sabbatical project proposal at the professor David H. Sherman research group

Grant number: 14/05670-7
Support type:Scholarships abroad - Research
Effective date (Start): July 25, 2014
Effective date (End): February 24, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Roberto Gomes de Souza Berlinck
Grantee:Roberto Gomes de Souza Berlinck
Host: David H. Sherman
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Local de pesquisa : University of Michigan, United States  


We propose to investigate biosynthetic gene clusters of guanidine alkaloids found in a Brazilian specimen of the sponge Monanchora arbuscula. These alkaloids constitute unique chemical entities, which seem to be polyketide-derived, for which a guanidine-derived amino acid can be envisaged as a starting biosynthetic group, possibly derived from arginine. The biosynthetic origin of marine sponge guanidine alkaloids have not yet been investigated. Considering that such alkaloids have an occurrence as very complex mixtures, the investigation of the biosynthetic gene clusters coding for guanidine alkaloids biosynthesis in marine sponges may constitute a considerable challenge to be achieved. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NEWMISTER, SEAN A.; ROMMINGER, STELAMAR; SCHMIDT, JENNIFER J.; WILLIAMS, ROBERT M.; SMITH, JANET L.; BERLINCK, ROBERTO G. S.; SHERMAN, DAVID H. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 16, n. 35, p. 6450-6459, SEP 21 2018. Web of Science Citations: 6.
NEWMISTER, SEAN A.; GOBER, CLAIRE M.; ROMMINGER, STELAMAR; YU, FENGAN; TRIPATHI, ASHOOTOSH; PARRA, LIZBETH LORENA L.; WILLIAMS, ROBERT M.; BERLINCK, ROBERTO G. S.; JOULLIE, MADELEINE M.; SHERMAN, DAVID H. OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30. Journal of the American Chemical Society, v. 138, n. 35, p. 11176-11184, SEP 7 2016. Web of Science Citations: 12.
BERLINCK, ROBERTO G. S.; ROMMINGER, STELAMAR. The chemistry and biology of guanidine natural products. NATURAL PRODUCT REPORTS, v. 33, n. 3, p. 456-490, 2016. Web of Science Citations: 40.

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