The research of pathogens in blood donors can contribute significantly to improve the quality of blood products and the safety concern. Currently, blood banks (in Brazil or around the globe?), perform serological screening only for seven agents (Hepatitis, HTLV, HIV, Syphilis and Chagas). However, many other agents known or yet unidentified might be are present in samples from donors. The aim of this study is to investigate the possible presence of known or unknown pathogens present in samples from Brazilian blood donors. Next-generation sequencing (NGS) is currently a methodology widely applied to search for new agents allowing the generation of millions of sequences from a single sample with potential for disease diagnostics. In the literature, numerous Metagenomic techniques for detecting pathogens are described, however these techniques present variations depending on the type of materials and microorganisms to be studied. The group of Dr. Eric Delwart is one of the pioneers in Metagenomic. The group performs analysis on animal samples and have in the literature numerous articles describing new viruses and related reviews. Similar to sequencing, molecular phylogeny is another area that has also undergone great revolutions in recent years. Epidemiological analyzes today are very common in phylogenetic analysis. The estimates of infection rates, path of the epidemic, local evolutionary traits, intra diversity host and innumerous of other applications are used by molecular phylogeny. The training in these techniques will be of great importance in the current study of the student as well as of great importance for our research group after their return. (AU)
News published in Agência FAPESP Newsletter about the scholarship:
PHAN, TUNG GIA;
DA COSTA, ANTONIO CHARLYS;
A new gyrovirus in human feces.
Web of Science Citations: 7.