Anti-inflammatory effect of exercise on insulin sensitivity in skeletal muscle of obese rodents: role of interleukin 10

• Grant number: 13/23723-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): June 01, 2014
• Effective date (End): May 31, 2017
• Field of knowledge: Biological Sciences - Physiology - Physiology of Effort
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: José Rodrigo Pauli
• Grantee: Eloize Cristina Chiarreotto Ropelle
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil

Abstract

Skeletal muscle represents approximately 40 % of total body mass and plays a critical role in glucose metabolism. Low grade inflammation observed in obese is directly related to insulin resistance in skeletal muscle through the activation of protein serine kinases including JNK and IKK b which attenuate insulin sensitivity through the serine phosphorylation of insulin receptor and insulin receptor substrate, reducing the insulin signal transduction. Moreover, the exercise is considered one of the most non-pharmacological strategies for preventing or treating disorders related to insulin sensitivity. It is well stablished that aerobic exercise is able to suppress the deleterious effects of inflammation on insulin sensitivity. Usually, the chronic effects of exercise are associated with to the reduction of body weight, in particular in fat mass. Interestingly, acutely, exercise is able to suppress inflammatory pathways, attenuate the activity of serine kinase (JNK and IKK b) and restored insulin sensitivity in skeletal muscle of obese and type 2 diabetics. In recent years, these anti-inflammatory effects seen promoted by year are attributed to molecules secreted by muscle contraction, among these molecules highlight IL-6, IL-10, IL- 1ra and sTNFR. However the effects of these molecules on insulin sensitivity remain only partially understood. Thus, the current project aims to investigate the specific role of IL - 10 on inflammation and insulin sensitivity in skeletal muscle of obese rodents after acute exercise session. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ROPELLE, Eloize Cristina Chiarreotto. The antiinflamatory effect of exercise on insilin sensibility in the skeletal muscle of obese rodents: the role of interleukin 10. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.