Evaluation of the antiinflammatory effect of Tnp in subcutaneous treatment of EAE compared with Glatiramer

• Grant number: 14/09249-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): July 01, 2014
• Effective date (End): December 31, 2015
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Carla Lima da Silva
• Grantee: Taís Aparecida Matozo de Souza
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an experimentally induced inflammatory central nervous system (CNS) demyelinating disease that mimics many aspects of multiple sclerosis (MS). The venom of Thalassophryne nattereri Brazilian fish is a complex mixture that includes proteases and small molecules both used as pharmacological tools for the development of new drugs. Recently we described that the Tnp a small peptide present in the venom has an important anti-inflammatory effect in EAE reducing the symptoms of the disease and promoting the delay in the beginning of the peak of symptoms. Here the aim of this study is the comparison of the benefic effect of Tnp versus the approved drug Glatiramer. For this we will use (MOG35-55 peptide)-induced EAE in female C57BL/6 and three treatment regimens: Prophylactic (days 0 to 10), therapeutical (days 11 to 20), and continuous (0 to 20). (AU)