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Aluminum chloride and aluminum fluoride added to MTA Angelus to inhibit the dental discolouration: evaluation of physical, chemical and biological properties

Grant number: 14/01003-6
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2014
Effective date (End): July 31, 2016
Field of knowledge:Health Sciences - Dentistry - Endodontics
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Marco Antonio Hungaro Duarte
Grantee:Marina Angélica Marciano da Silva
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


White MTA has different applications in Endodontics, due to its satisfactory biological properties. However, white MTA causes discoloration of dental structures, an undesirable consequence especially in aesthetical areas. The destabilization of bismuth oxide molecule has been pointed as the cause of discoloration. The aim of the study is to evaluate the addition of aluminium chloride and aluminium fluoride in white MTA to inhibit the destabilization of bismuth oxide and the dental discoloration. The proportions of 0.5; 1.0 and 3.0% of the substances will be added, by weigh, in white MTA. The chemical characterization, radiopacity, setting time, solubility, pH, calcium and fluoride release, dental discoloration and biocompatibility will be evaluated. White MTA will be the control. The cements will be mixed using 1 g of powder to 0.3 mL of distilled water. Chemical characterization will be evaluated using SEM, EDS and XRD. Radiopacity and setting time will be determined according to ISO 6876/2001. Volumetric solubility will be tested using micro-CT. The pH and ion release will be evaluated after 3, 24 hours and 28 days. Dental discoloration analysis will be performed before cement insertion, immediately after insertion and after 28, 60, 90 and 180 days. The biocompatibility will be evaluated with the implantation of cements in subcutaneous tissue of rats. The results will be submitted to normality test of D'Agostino and Pearson to select the most adequate statistical test (p < 0.05). (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCIANO, MARINA ANGELICA; GUIMARAES, BRUNO MARTINI; AMOROSO-SILVA, PABLO; CAMILLERI, JOSETTE; HUNGARO DUARTE, MARCO ANTONIO. Physical and Chemical Properties and Subcutaneous Implantation of Mineral Trioxide Aggregate Mixed with Propylene Glycol. JOURNAL OF ENDODONTICS, v. 42, n. 3, p. 474-479, . (13/04054-8, 14/01003-6)
DUQUE, J. A.; FERNANDES, S. L.; BUBOLA, J. P.; DUARTE, M. A. H.; CAMILLERI, J.; MARCIANO, M. A.. The effect of mixing method on tricalcium silicate-based cement. International Endodontic Journal, v. 51, n. 1, p. 69-78, . (15/01934-2, 14/01003-6)
MARCIANO, MARINA ANGELICA; CAMILLERI, JOSETTE; COSTA, REGINALDO MENDONCA; MATSUMOTO, MARIZA AKEMI; GUIMARAES, BRUNO MARTINI; HUNGARO DUARTE, MARCO ANTONIO. Zinc Oxide Inhibits Dental Discoloration Caused by White Mineral Trioxide Aggregate Angelus. JOURNAL OF ENDODONTICS, v. 43, n. 6, p. 1001-1007, . (14/01003-6)
MARCIANO, MARINA ANGELICA; CAMILLERI, JOSETTE; LUCATELI, RIBAMAR LAZANHA; COSTA, REGINALDO MENDONCA; MATSUMOTO, MARIZA AKEMI; HUNGARO DUARTE, MARCO ANTONIO. Physical, chemical, and biological properties of white MTA with additions of AlF3. CLINICAL ORAL INVESTIGATIONS, v. 23, n. 1, p. 33-41, . (14/01003-6, 17/05096-7)

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