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HPLC/DAD/MS chemical profile of Vochysia divergens plants cultured under drought stress associated with endophytic fungi and evaluation of antioxidant and neuroprotective activities

Grant number: 13/22030-9
Support type:Scholarships in Brazil - Master
Effective date (Start): July 01, 2014
Effective date (End): June 30, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Ana Helena Januário
Grantee:Letícia Pereira Pimenta
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

Vochysia divergens Pohl (Vochysiaceae) is a native species from the Pantanal biome, popularly known as Cambará. This master's project intents to investigate the chemical profile by HPLC-DAD-MS plants of V. divergens cultured under drought stress conditions and elicitation with two different strains of endophytic fungi in comparison with the respective controls. The 3',5-dimethoxyluteolin-7-O-²-glucoside and 3',5-dimethoxy-luteolin flavones obtained from V. divergens in a previous study will be used as internal standards in quantitative analyzes along with other natural substances to be isolated. Additionally, antioxidant and neuroprotective assays will be held evaluating the biological potential of isolated compounds. Thus, the main goal of this proposal will be investigate whether inoculation with endophytic fungi aids in the process of host plant resistance to drought stress and either alters the metabolic profile of V. divergens therefore intensifying its antioxidant and neuroprotective potential. This project also aims to contribute to the training of human resources in the area of natural products in the state of São Paulo in a multidisciplinary approach. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PIMENTAA, LETICIA PEREIRA; KELLNER FILHO, LUIS CLADIO; SOARES PARPINELLI, BRUNA ARRUDA; DE SIQUEIRA, KATIA APARECIDA; SOARES, MARCOS ANTONIO; ANDRADE E SILVA, MARCIO LUIS; CUNHA, WILSON ROBERTO; PAULETTI, PATRICIA MENDONCA; JANUARIO, ANA HELENA. DEVELOPMENT AND VALIDATION OF AN HPLC-DAD ANALYTICAL METHOD TO QUANTIFY 5-METHOXYFLAVONES IN METHANOLIC EXTRACTS OF Vochysia divergens POHL CULTURED UNDER STRESS CONDITIONS. Química Nova, v. 40, n. 9, p. 971-975, . (13/15774-1, 11/00631-5, 13/22030-9, 16/08057-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.