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Lipidomics shotgun in giardiasis, meningitis and tuberculosis: the search of diagnostic markers, using revolutionary new techniques of mass spectrometry

Grant number: 14/00302-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2014
Effective date (End): March 31, 2017
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Rodrigo Ramos Catharino
Grantee:Cibele Zanardi Esteves
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Following advances in genomics and proteomics, new fields of "omics" are emerging. The metabolomics course complements studies in the area of genomics and proteomics, however great physical chemistry metabolome diversity leads to a subdivision of metabolites. Thus, lipidomics is currently emerging as a discipline in the interface of biochemistry of lipids, technology and medicine. This expansion of the field of lipidomics can be attributed to analytical advances, particularly in the development of new techniques of mass spectrometry for the characterization and quantification of the different species of lipids present in a lipidome. Lipids play important roles in cell composition among them membrane composition, energy supply and signal transduction, and therefore can be used as biomarkers in metabolic diseases, infectious diseases and degenerative diseases. The aim of this study is the determination of lipid biomarkers present the etiological agents of giardiasis, meningitis and tuberculosis, as well as lipid biomarkers involved in the progression and treatment of meningitis by mass spectrometry and development of diagnostic methods for giardiasis, meningitis and tuberculosis directly from the feaces, cerebrospinal fluid and sputum, respectively. The development of diagnostic methods based on mass spectrometry can provide a rapid and sensitive diagnosis, allowing rapid patient care and reducing the transmission of these diseases (AU)

Articles published in Agência FAPESP about the scholarship:
Test promises to diagnose cystic fibrosis more accurately 

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ODIR RODRIGUES MELO, CARLOS FERNANDO; NAVARRO, LUIZ CLAUDIO; DE OLIVEIRA, DIOGO NOIN; GUERREIRO, TATIANE MELINA; LIMA, ESTELA DE OLIVEIRA; DELAFIORI, JEANY; DABAJA, MOHAMED ZIAD; RIBEIRO, MARTA DA SILVA; DE MENEZES, MAICO; MARTINS RODRIGUES, RAFAEL GUSTAVO; MORISHITA, KAREN NODA; ESTEVES, CIBELE ZANARDI; LUCAS DE AMORIM, ALINE LOPES; AOYAGUI, CAROLINE TIEMI; PARISE, PIERINA LORENCINI; MILANEZ, GUILHERME PAIER; DO NASCIMENTO, GABRIELA MANSANO; RIBAS FREITAS, ANDRE RICARDO; ANGERAMI, RODRIGO; MARANHAO COSTA, FABIO TRINDADE; ARNS, CLARICE WEIS; RESENDE, MARIANGELA RIBEIRO; AMARAL, ELIANA; PASSINI JUNIOR, RENATO; RIBEIRO-DO-VALLE, CAROLINA C.; MILANEZ, HELAINE; MORETTI, MARIA LUIZA; PROENCA-MODENA, JOSE LUIZ; AVILA, SANDRA; ROCHA, ANDERSON; CATHARINO, RODRIGO RAMOS; NETWORK, ZIKA-UNICAMP. A Machine Learning Application Based in Random Forest for Integrating Mass Spectrometry-Based Metabolomic Data: A Simple Screening Method for Patients With Zika Virus. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 6, APR 11 2018. Web of Science Citations: 0.
LIMA, ESTELA DE O.; GUERREIRO, TATIANE M.; MELO, CARLOS FERNANDO O. R.; DE OLIVEIRA, DIOGO N.; MACHADO, DAISY; LANCELLOTI, MARCELO; CATHARINO, RODRIGO R. MALDI imaging detects endogenous digoxin in glioblastoma cells infected by Zika virusWould it be the oncolytic key?. Journal of Mass Spectrometry, v. 53, n. 3, p. 257-263, MAR 2018. Web of Science Citations: 1.
ESTEVES, CIBELE ZANARDI; DIAS, LETICIA DE AGUIAR; LIMA, ESTELA DE OLIVEIRA; DE OLIVEIRA, DIOGO NOIN; ODIR RODRIGUES MELO, CARLOS FERNANDO; DELAFIORI, JEANY; SOUZA GOMEZ, CARLA CRISTINA; RIBEIRO, JOSE DIRCEU; RIBEIRO, ANTONIO FERNANDO; LEVY, CARLOS EMILIO; CATHARINO, RODRIGO RAMOS. Skin Biomarkers for Cystic Fibrosis: A Potential Non-Invasive Approach for Patient Screening. FRONTIERS IN PEDIATRICS, v. 5, JAN 10 2018. Web of Science Citations: 0.
MELO, CARLOS FERNANDO O. R.; DELAFIORI, JEANY; DE OLIVEIRA, DIOGO N.; GUERREIRO, TATIANE M.; ESTEVES, CIBELE Z.; LIMA, ESTELA DE O.; PANDO-ROBLES, VICTORIA; CATHARINO, RODRIGO R.; NETWORK, ZIKA-UNICAMP. Serum Metabolic Alterations upon Zika Infection. FRONTIERS IN MICROBIOLOGY, v. 8, OCT 10 2017. Web of Science Citations: 9.
ODIR RODRIGUES MELO, CARLOS FERNANDO; ESTEVES, CIBELE ZANARDI; DE OLIVEIRA, ROSIMEIRE NUNES; GUERREIRO, TATIANE MELINA; DE OLIVEIRA, DIOGO NOIN; LIMA, ESTELA DE OLIVEIRA; MINE, JULIO CESAR; ALLEGRETTI, SILMARA MARQUES; CATHARINO, RODRIGO RAMOS. Early developmental stages of Ascaris lumbricoides featured by high-resolution mass spectrometry. Parasitology Research, v. 115, n. 11, p. 4107-4114, NOV 2016. Web of Science Citations: 1.
ODIR RODRIGUES MELO, CARLOS FERNANDO; DE OLIVEIRA, DIOGO NOIN; LIMA, ESTELA DE OLIVEIRA; GUERREIRO, TATIANE MELINA; ESTEVES, CIBELE ZANARDI; BECK, RAISSA MARQUES; PADILLA, MARINA AIELLO; MILANEZ, GUILHERME PAIER; ARNS, CLARICE WEIS; PROENCA-MODENA, JOSE LUIZ; SOUZA-NETO, JAYME AUGUSTO; CATHARINO, RODRIGO RAMOS. A Lipidomics Approach in the Characterization of Zika-Infected Mosquito Cells: Potential Targets for Breaking the Transmission Cycle. PLoS One, v. 11, n. 10 OCT 10 2016. Web of Science Citations: 11.
FERREIRA, MONICA SIQUEIRA; DE OLIVEIRA, ROSIMEIRE NUNES; DE OLIVEIRA, DIOGO NOIN; ESTEVES, CIBELE ZANARDI; ALLEGRETTI, SILMARA MARQUES; CATHARINO, RODRIGO RAMOS. Revealing praziquantel molecular targets using mass spectrometry imaging: an expeditious approach applied to Schistosoma mansoni. International Journal for Parasitology, v. 45, n. 6, p. 385-391, MAY 2015. Web of Science Citations: 10.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.

Filed patent(s) as a result of this research project

MÉTODO DE DETECÇÃO E IDENTIFICAÇÃO DE BIOMARCADOR(ES) LIPÍDICO(S) ESPECÍFICO(S) PARA HANSENÍASE BR1020150216726 - Universidade Estadual de Campinas (UNICAMP) . Rodrigo Ramos Catharino; Estela De Oliveira Lima; Cibele Zanardi Esteves; Diogo Noin De Oliveira; Cristiana Santos De Macedo; José Augusto Da Costa Nery; Maria Cristina Vidal Pessolani; Euzenir Nunes Sarno - September 2015, 04

MÉTODO PARA DETECÇÃO E IDENTIFICAÇÃO DE MARCADORES PARA FIBROSE CÍSTICA NA PELE E SEU USO BR1020170054632 - Universidade Estadual de Campinas (UNICAMP) . Rodrigo Ramos Catharino; José Dirceu Ribeiro; Antônio Fernando Ribeiro; Carlos Emilio Levy; Carla Cristina Souza Gomez; Estela de Oliveira Lima; Letícia de Aguiar Dias; Carlos Fernando Odir Rodrigues Melo; Diogo Noin de Oliveira; Cibele Zanardi Esteves - March 2017, 17

MÉTODO DE IDENTIFICAÇÃO DE BIOMARCADORES PARA COLESTASE NEONATAL, KIT DE IDENTIFICAÇÃO DOS BIOMARCADORES E USO PCT/BR2017/000151 - Universidade Estadual de Campinas (UNICAMP) . Rodrigo Ramos Catharino; Maria Angela Bellomo Brandao; Gabriel Hessel; Letícia de Aguiar Dias; Carlos Fernando Odir Rodrigues Melo; Diogo Noin de Oliveira (FCM); Cibele Zanardi Esteves - December 2017, 19