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Characterization of Cordia verbenacea DC sustained release using natural latex biomembranes as carrier

Grant number: 14/11037-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2014
Effective date (End): July 31, 2015
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal Investigator:Rondinelli Donizetti Herculano
Grantee:Vitória de Sousa Chao
Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil


The Natural Rubber Latex (NRL) membrane manipulated from the latex extracted from the rubber tree Hevea brasiliensis, has shown great potential for biomedical applications and as biomaterials. Due to its biocompatibility and low risk of rejection, it can stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, besides acting as a mechanical barrier to infectious agents. The aim of this study is to develop a novel sustained delivery system for Cordia verbenacea DC. based on Natural Rubber Latex (NRL) membranes and to study the Cordia Verbenacea DC. delivery system behavior. The Cordia Verbenacea DC. is an anti-inflammatory, anti-ulcer, anti-rheumatic and healing plant that has therapeutic properties and low toxicity, thanks to the action of the essential oil, which has the active ingredient alpha-humulene. The use of a controlled release system, coupled with the angiogenic properties of latex, seeking to extract-biomembrane interaction, and thus ensure the improvement of the effects of the herbal medicine, as well as offering a cheaper and affordable alternative to those existing in market. The release rates of extract the complex drug-extract-film will be monitored and analyzed, using the method of optical spectroscopy (UV-VIS), and will be characterized by Scanning Electron Microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and mechanical resistance tests.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FLORIANO, JULIANA F.; CHAO, VITORIA DE SOUSA; BOLOGNESI, LUIS F. C.; DE BARROS, NATAN R.; MIRANDA, MATHEUS C. R.; BORGES, FELIPE A.; CHAGAS, ANA LAURA D.; PAULINO, CRISTIANE G.; GARMS, BRUNA C.; MARCELINO, MONICA Y.; et al. Physical, Chemical and Biological Characterization of Natural Rubber Latex Membranes Loaded with Cordia verbenacea DC. Extract. JOURNAL OF FUNGI, v. 4, n. 2, p. 140-154, . (14/17526-8, 14/11037-5, 11/17411-8)

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