MicroRNome of pancreatic câncer

• Grant number: 14/00367-4
• Support type: Scholarships in Brazil - Master
• Effective date (Start): June 01, 2014
• Effective date (End): January 31, 2016
• Field of knowledge: Health Sciences - Medicine - Surgery
• Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal researcher: Patricia Pintor dos Reis
• Grantee: Tainara Francini Felix
• Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Pancreatic carcinoma has high mortality rates, usually associated with late diagnosis. The identification of biomarkers and molecular mechanisms associated with pancreatic tumorigenesis may be useful for the development of directed treatment, which will ultimately lead to improved patient prognosis. In fact, the identification of biomarkers and molecular pathways has led to the development of more precise therapeutic strategies in other malignant solid tumors, such as breast and lung carcinomas. The objective of this study is to identify global microRNA (miRNA) profiles and target genes potentially regulated by miRNAs in pancreatic adenocarcinoma, the main histological type of pancreatic cancers. miRNAs are important gene expression regulators and have been suggested as biomarkers with diagnostic, prognostic and predictive value in several cancer types. Target genes potentially regulated by miRNAs, once identified and mapped into proteins, may lead to the characterization of important molecular pathways in pancreatic oncogenesis. In addition, miRNA expression data will be integrated with global miRNA sequencing data in pancreatic adenocarcinoma publicly available at the Cancer Genome Atlas Project (CGAP). Characterization of molecular pathways in these tumors may contribute for the future development of novel therapeutic strategies for treatment of patients with pancreatic adenocarcinoma. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FELIX, TAINARA F.; LOPEZ LAPA, RAINER M.; DE CARVALHO, MARCIO; BERTONI, NATALIA; TOKAR, TOMAS; OLIVEIRA, ROGERIO A.; RODRIGUES, MARIA A. M.; HASIMOTO, CLAUDIA N.; OLIVEIRA, WALMAR K.; PELAFSKY, LEONARDO; et al. MicroRNA modulated networks of adaptive and innate immune response in pancreatic ductal adenocarcinoma. PLoS One, v. 14, n. 5, MAY 31 2019. (14/00367-4, 16/03905-2)

ANGELINI, MARCOS C.; SILVA, ALANA MAIA E.; FELIX, TAINARA F.; LAPA, RAINER M. L.; TERRA, SIMONE A.; RODRIGUES, MARIA A. M.; ORTOLAN, ERIKA V. P.; REIS, PATRICIA P.; LOURENCAO, PEDRO L. T. A.. Identification of potential molecular pathogenesis mechanisms modulated by microRNAs in patients with Intestinal Neuronal Dysplasia type B. SCIENTIFIC REPORTS, v. 9, NOV 27 2019. (14/04271-1, 15/03664-2, 14/00367-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FELIX, Tainara Francini. MicroRNoma of the pancreatic carcinoma. 2016. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.