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Effects of cetuximab treatment in the behaviour of cancer stem cell in oral squamous cell carcinoma

Grant number: 14/12658-3
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): October 01, 2014
Effective date (End): November 30, 2014
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Fabio Daumas Nunes
Grantee:Maria Fernanda Setúbal Destro Rodrigues
Supervisor: Ian Campbell Mackenzie
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Queen Mary University of London, England  
Associated to the scholarship:11/21395-8 - Functional analysis of cell signaling involvement in cancer stem cells obtained from oral squamous cell carcinoma cell lines, BP.PD


The initiation, growth, recurrence and metastasis of solid tumours, including oral squamous cell carcinoma (OSCC), have been related to the behaviour of a small subpopulation of 'tumour-initiating' cells. These cells, also called as cancer stem cells, drive tumour growth and are responsible for tumour aggressiveness and therapeutic resistance. One such targeted therapy of importance for the treatment of OSCC, Cetuximab, is anticipated to work by blocking the EGF receptor function of CSCs. Despite the substantial evidence concerning the central role of CSCs in malignant grow, very little is known about their responses to targeted therapies. The main purpose of the present study is to evaluate the effects of Cetuximab on CSC and non-CSC isolated based on their CD44 expression by Fluorescence-ativated Cell Sorting through analysis of their growth rates, apoptotic responses, and loss of stem cell properties. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BELIZARIO, JOSE E.; NEYRA, JENNIFER M.; SETUBAL DESTRO RODRIGUES, MARIA FERNANDA. When and how NK cell-induced programmed cell death benefits immunological protection against intracellular pathogen infection. Innate Immunity, v. 24, n. 8, p. 452-465, . (18/11053-1, 14/12658-3)

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