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Structural and biochemical evaluation by magnetic resonance imaging in temporal lobe epilepsy model in rats with and without status epilepticus

Grant number: 14/11277-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2014
Effective date (End): April 30, 2019
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Fernando Cendes
Grantee:Renata Barbosa
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:11/50680-2 - Multimodal investigation of epileptogenesis with emphasis in the implementation of new animal models and new tools, AP.TEM
Associated scholarship(s):17/25029-2 - Diffusion-weighted magnetic resonance imaging in the pilocarpine model of temporal lobe epilepsy, BE.EP.DR

Abstract

The mesial temporal lobe epilepsy (MTLE) is the epileptic syndrome more common and difficult treatment, because of large proportion of patients refractory to drug treatment. The relationship between hippocampal sclerosis and refractory TLE has been too much reported over the years, however its etiology and mechanisms responsible for hippocampal sclerosis which influences the seizures yet seem to partially obscure. Technological advance has provided tools in increasingly effective in neuroimaging for investigating clinical processes in epilepsy. Magnetic resonance imaging (MRI) has been considered the gold standard tool for these evaluations, it can reveal signs of hippocampal sclerosis, and other anatomical and metabolic changes. Animal models of epilepsy have significantly contributed in the expansion of the knowledge of the mechanisms and challenges shown by disease. Although structural changes in human and experimental models do not demonstrate all the similar features, these animals models are the best alternative for study the process of epileptogenesis and its causes and consequences. There are few longitudinal neuroimaging studies in animal models, so we will can to define dependable biomarkers for epileptogenesis in neuroimaging, improving the understanding of the mechanisms involved in animals, and the better understanding of changes in RM seen in humans after correlations between images and data histological at different stages of the process of epileptogenesis in experimental models. (AU)