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Study of modulation of the Wnt pathway by Aurora kinases inhibitor AMG 900 in pediatric medulloblastoma cell lines

Grant number: 14/07124-0
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2014
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Luiz Gonzaga Tone
Grantee:Lenisa Geron
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Medulloblastoma (MB) is the most common malignant brain tumor in childhood, but can also occur in adolescents and young adults. Currently used treatment includes surgical resection of tumor followed by local radiation and craniospinal and / or chemotherapy. Recently, the formation and progression of MB were associated with molecular alterations in different signaling pathways, for example, the Wingless (Wnt), known for its importance during cerebellar development. Recent studies suggest that Aurora-A and Aurora-B protein, which are essential for cell division and are active during mitosis, may be involved in the regulation of this pathway, during the progression of MB. Moreover, data from our group have shown that inhibition of the activity of Aurora-A and Aurora-B proteins by AM G900 in MB pediatric cells results in promising antineoplasic effects. However the mechanisms associated with this activity are still not fully elucidated. Thus, our objective is study the modulation of the Wnt pathway by Aurora kinases inhibitor AMG 900 in pediatric medulloblastoma cell lines. This research may provide new molecular perspectives, both to elucidate the specific mechanisms involved in the biology of MB, as for the identification of new therapeutic targets. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GERON, LENISA; SALOMAO, KARINA BEZERRA; BORGES, KLEITON SILVA; ANDRADE, AUGUSTO FARIA; PEREIRA CORREA, CAROLINA ALVES; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA. Molecular characterization of Wnt pathway and function of -catenin overexpression in medulloblastoma cell lines. Cytotechnology, v. 70, n. 6, p. 1713-1722, DEC 2018. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GERON, Lenisa. Study of Modulation of the Wnt pathway by Aurora kinases inhibitor AMG900 in pediatric medulloblastoma cell lines. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto Ribeirão Preto.

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