Study of the cytotoxic effect of the neuritogenic TCD4 lymphocytes over the Schwann Cells on the Experimental autoimmune neuritis

• Grant number: 14/03622-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2014
• End date: September 30, 2015
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Alessandro dos Santos Farias
• Grantee: Camila de Oliveira Vaz
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 11/18728-5 - Study of migratory, effector and regulatory pattern of autoreactive t lymphocytes, previously transduced with GFP in experimental demyelinating diseases, AP.JP

Abstract

Guillain-Barré syndrome (GBS) is an acute inflammatory disease of the peripheral nervous system, with considerable mortality. The experimental autoimmune neuritis (EAN)is the experimental model of the GBS, which culminates in the demyelination of the peripheral nerves. This response is mediated by Th1 / Th17 speacially. Despite, it is still to be elucidated how T cells would be capable to start the inflammatory process Preliminary results of our group show that activated neuritogenic TCD4 lymphocytes acquire a cytotoxic phenotype and express high levels of granzyme B. Thus, in this propose, we intend to evaluate whether those TCD4 lymphocytes infiltrated into the perpheral nerves could also act over Schwann cells.