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Obtaining ferromagnetic nanoparticles through hydrothermal systhesis assisted by microwave irradiation to aplicattion in magnetohyperthermia

Grant number: 14/16993-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2014
Effective date (End): September 30, 2015
Field of knowledge:Engineering - Materials and Metallurgical Engineering
Principal researcher:Alexandre Zirpoli Simões
Grantee:Breno Gonçalves Galvão Freire
Home Institution: Faculdade de Engenharia (FEG). Universidade Estadual Paulista (UNESP). Campus de Guaratinguetá. Guaratinguetá , SP, Brazil
Associated research grant:13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID


A variety of clinical procedures has been developed for cancer therapy over the last century. Cancer is characterized by out of control cell growth. A tumor is an abnormal lump or collection of these cells. Tumors can be benign or malignant. In both cases, cells multiply in a disorderly manner. Benign tumors tend to grow slowly and do not spread. Malignant tumors can grow rapidly, invade and destroy nearby normal tissues, and spread throughout the body, phenomenon known as metastasis. Surgery, chemotherapy, and radiation are the most common types of cancer treatment. The development of hyperthermia improved cancer therapy and, in liver cancer, radiotherapy and surgery are limited. Hyperthermia can also enhance the effects of chemotherapy or radiotherapy. This treatment is based on the use of ferromagnetic nanoparticles made of Yƒ3Fe5-xAlxO12 (x entre 1,6 e 1,7) to remotely induce local heat when a radiofrequency magnetic field is applied, provoking a temperature increase (41-43 °C) in those tissues and organs where the tumoral cells are present. These nanoparticles have interesting physical properties, such as high saturation magnetization and controllable Curie temperature, characteristics that are particularly interesting for hyperthermia. This project aims to synthesize and characterize ferromagnetic nanoparticles Yƒ3Fe5-xAlxO12 (x entre 1,6 e 1,7) using hydrothermal technique assisted by microwave. This technique is less expensive and more efficient than conventional autoclave methods, generating nanoparticles more homogeneous and crystalline in lower temperatures during the synthesis. The objective of this project is study the necessary conditions to utilize these nanoparticles in liver cancer treatment by hyperthermia.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BORSARI, E.; FREIRE, B. G. G.; GARCIA, F. G.; SILVA, M. S.; SILVA, C. C.; SIMOES, A. Z. Microwave-hydrothermal synthesis of Y3Fe3.35Al1.65O12 nanoparticles for magneto-hyperthermia application. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, v. 29, n. 21, p. 18020-18029, NOV 2018. Web of Science Citations: 0.

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