Identification of intermediates formed during degradation of veterinary drugs by advanced oxidation processes

• Grant number: 14/16622-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: October 01, 2014
• End date: April 30, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Susanne Rath
• Grantee: Caio Alexandre Augusto Rodrigues da Silva
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/09543-7 - Residues of veterinary drugs in the environment, AP.TEM

Abstract

Sulfonamides are a group of synthetic antimicrobial drugs containing more than 150 substances, which operate in the nucleic acids of the target microorganism by inhibiting bacterial growth. Since 1982 the sulfonamides have been detected in bodies of water from various countries such as USA, France and China. In conjunction with the sulfonamides, the tetracyclines are now the second most common group of antibiotics in the world, both in production and in use, and are mainly utilized in the treatment of diseases in both humans and livestock. The fluoroquinolones, in turn, are commonly used in veterinary medicine to treat infections by gram-positive and gram-negative organisms. Much of the administered doses of these drugs are excreted via urine and/or faeces; consequently, considerable quantities are often found in sewage treatment plants effluents as well as in surface water and groundwater in the range of ¼g L-1 to ng L-1. Due to the constant introduction of these drugs into the environment and its difficult removal and degradation in aqueous media they are considered persistent, being their presence in the environment a contributing factor to the development of resistant bacteria. This project will assess the application of photocatalysis to the degradation of veterinary drugs, which belong to the classes of sulfonamides, tetracyclines and fluoroquinolones. Furthermore, it is important to highlight that the emphasis will be on the synthesis of photocatalytic nanomaterial for application in the photocatalysis of these substances. Moreover, the intermediates formed during the application of the advanced oxidation process proposed will be assessed.

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES-SILVA, CAIO; MONTEIRO, RICARDO A. R.; DEZOTTI, MARCIA; SILVA, ADRIAN M. T.; PINTO, EUGENIA; BOAVENTURA, RUI A. R.; VILAR, VITOR J. P.. A facile method to prepare translucent anatase thin films in monolithic structures for gas stream purification. Environmental Science and Pollution Research, v. 25, n. 28, SI, p. 27796-27807, OCT 2018. (14/16622-3)

FERREIRA, FABRICIO DE OLIVEIRA; RODRIGUES-SILVA, CAIO; RATH, SUSANNE. On-line solid-phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry for the determination of avermectins and milbemycin in soils. Journal of Chromatography A, v. 1471, p. 118-125, NOV 4 2016. (13/09543-7, 14/16622-3, 13/25670-9)

TETZNER, NATALIA FERNANDA; MANIERO, MILENA GUEDES; RODRIGUES-SILVA, CAIO; RATH, SUSANNE. On-line solid phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry as a powerful technique for the determination of sulfonamide residues in soils. Journal of Chromatography A, v. 1452, p. 89-97, JUN 24 2016. (13/07817-2, 13/09543-7, 14/16622-3, 14/06201-0)

PORTO, RAFAEL SILVEIRA; RODRIGUES-SILVA, CAIO; SCHNEIDER, JERUSA; RATH, SUSANNE. Benzimidazoles in wastewater: Analytical method development, monitoring and degradation by photolysis and ozonation. Journal of Environmental Management, v. 232, p. 729-737, FEB 15 2019. (13/09543-7, 14/16622-3, 14/50951-4, 18/03571-2)

CAIANELO, MARLON; RODRIGUES-SILVA, CAIO; MANIERO, MILENA GUEDES; DINIZ, VINICIUS; SPINA, MYLENA; GUIMARAES, JOSE ROBERTO. Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation. WATER SCIENCE AND TECHNOLOGY, v. 84, n. 1, p. 225-236, JUL 1 2021. (18/03571-2, 14/50951-4, 13/09543-7, 14/16622-3)

CAIANELO, MARLON; RODRIGUES-SILVA, CAIO; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Antimicrobial activity against Gram-positive and Gram-negative bacteria during gatifloxacin degradation by hydroxyl radicals. Environmental Science and Pollution Research, v. 24, n. 7, p. 6288-6298, MAR 2017. (14/16622-3, 14/06064-3, 13/09543-7, 13/04656-8, 13/07817-2, 14/06201-0)

LIMA VENANCIO, WILSON AUGUSTO; RODRIGUES-SILVA, CAIO; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Photocatalytic removal of fluoroquinolones and their antimicrobial activity from water matrices at trace levels: a comparison of commercial TiO2 catalysts. WATER SCIENCE AND TECHNOLOGY, v. 78, n. 8, p. 1668-1678, NOV 2018. (14/06201-0, 13/07817-2, 13/09543-7, 14/16622-3, 14/06064-3)

DUARTE DE OLIVEIRA, AMANDA MARCHI; MANIERO, MILENA GUEDES; RODRIGUES-SILVA, CAIO; GUIMARAES, JOSE ROBERTO. Antimicrobial activity and acute toxicity of ozonated lomefloxacin solution. Environmental Science and Pollution Research, v. 24, n. 7, p. 6252-6260, MAR 2017. (13/04656-8, 13/09543-7, 13/07817-2, 14/16622-3)

RODRIGUES-SILVA, CAIO; MIRANDA, SANDRA M.; LOPES, FILIPE V. S.; SILVA, MARIO; DEZOTTI, MARCIA; SILVA, ADRIAN M. T.; FARIA, JOAQUIM L.; BOAVENTURA, RUI A. R.; VILAR, VITOR J. P.; PINTO, EUGENIA. Bacteria and fungi inactivation by photocatalysis under UVA irradiation: liquid and gas phase. Environmental Science and Pollution Research, v. 24, n. 7, p. 6372-6381, MAR 2017. (14/16622-3)

RODRIGUES-SILVA, CAIO; MONTEIRO, RICARDO A. R.; DEZOTTI, MARCIA; SILVA, ADRIAN M. T.; PINTO, EUGENIA; BOAVENTURA, RUI A. R.; VILAR, VITOR J. P.. A facile method to prepare translucent anatase thin films in monolithic structures for gas stream purification. Environmental Science and Pollution Research, v. 25, n. 28, p. 12-pg., 2018-10-01. (14/16622-3)