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Betalainic amides and esters: preparation and photophysical properties

Grant number: 14/16608-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2014
Effective date (End): February 28, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Erick Leite Bastos
Grantee:Luiza Rodrigues Neder Issa
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


This undergraduate research project proposes the conversion of carboxylic portions of betalains in amides and esters as well as the determination of the effect of structural change on the photophysical properties and thermal stability of betalains. Two model betalains were selected: betanin (Bn), a non-toxic and water-soluble pigment obtained from the red beet, and betacoumarin-120 (Btc-120) a semisynthetic betalaine used as a fluorescent probe in quantification of erythrocytes infected with Plasmodium falciparum. The preparations will be carried out using three amines and two alcohols and two different carbodiimides will be used as coupling agents.