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Effect of diphenyl diselenide (PhSe)2 on biofilm formation by Candida albicans

Grant number: 14/14148-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2014
Effective date (End): October 31, 2016
Field of knowledge:Engineering - Biomedical Engineering - Medical Engineering
Principal researcher:Maricilia Silva Costa
Grantee:Marília Toledo Braga
Home Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil


Candida albicans is an opportunistic fungal able to produces both superficial and systemic infections in immunocompromised patients. It has been demonstrated that biofilms formed by Candida albicans are resistant to different antifungal drugs, therefore, the infections related to biofilm formation are, frequently, refractory to the conventional therapy. Thus, the development of more effective antifungal therapies, especially against infections associated to biofilm becomes vital. It has been demonstrated the ability of different organochalcogenide compounds to inhibit both growth and germ tube formation by Candida albicans. The objective of this work is to study the effect of the organochalcogenide compound (PhSe)2 on biofilm formation by Candida albicans.

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