Uma intervenção Farmacológica para prevenir os efeitos da obesidade materna sobre a resistência à insulina no tecido adiposo da prole

• Grant number: 14/17012-4
• Support type: Scholarships abroad - Research Internship - Doctorate
• Effective date (Start): February 27, 2015
• Effective date (End): February 26, 2016
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Gabriel Forato Anhê
• Grantee: Juliana de Almeida Faria
• Supervisor abroad: Susan Ozanne
• Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Local de pesquisa : University of Cambridge, England
• Associated to the scholarship: 12/11409-4 - Relationship between time of fructose intake and hypothalamic AMPK rhythm: possible connections of the metabolic outcome with melatonin production, BP.DR

Abstract

Increasing evidence from studies in humans and animal models suggests that maternalobesity during pregnancy can, through non-genetic mechanisms, increase the risk ofcardiovascular dysfunction, insulin resistance, type 2 diabetes and other features of themetabolic syndrome in the offspring. However, the components of the in uteroenvironment that mediate the effects of maternal obesity on offspring health are not fullyunderstood. The aim of the current study is to determine whether a clinically relevantintervention to improve glucose homeostasis and insulin sensitivity during an obesepregnancy can prevent the development of insulin resistance and associated molecularchanges in the offspring using a well-characterised mouse model of maternal diet-inducedobesity. These studies in experimental animals will help define mechanisms by whichmaternal obesity leads to increased risk of the metabolic syndrome in the offspring and willdirectly inform strategies in pregnant obese women to improve the health of her child. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE ALMEIDA-FARIA, JULIANA; DUQUE-GUIMARAES, DANIELLA E.; ONG, THOMAS P.; PANTALEAO, LUCAS C.; CARPENTER, ASHA A.; LOCHE, ELENA; KUSINSKI, LAURA C.; ASHMORE, THOMAS J.; ANTROBUS, ROBIN; BUSHELL, MARTIN; FERNANDEZ-TWINN, DENISE S.; OZANNE, SUSAN E. Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark. Diabetologia, JAN 2021. Web of Science Citations: 0.

FARIA, JULIANA DE ALMEIDA; DUQUE-GUIMARAES, DANIELLA; CARPENTER, ASHA A. M.; LOCHE, ELENA; OZANNE, SUSAN E. A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue. SCIENTIFIC REPORTS, v. 7, MAR 24 2017. Web of Science Citations: 7.