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Neurotoxicity of anhydroecgonine methyl ester in vitro: apoptosis death pathway caracterization and the autophagic process involvent

Grant number: 13/20952-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2014
Effective date (End): August 31, 2017
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Tania Marcourakis
Grantee:Mariana Sayuri Berto Udo
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The growing number of crack users is already considered a great public health issue, not only in Brazil but all around the world. Crack is widely associated with sexual diseases due to prostitution, violent and criminal behavior, medical and psychiatric complications and also increase in morbidity and mortality rate. The choose of smokable cocaine is due to its intense effects. The crack users are also under the effects of cocaine pyrolysis product, the anhydroecgonine methyl ester (AEME), but the knowledge about the effects of AEME is scarce. There are evidences that the acute and chronic cocaine use leads to neurodegeneration. There are many mechanisms that lead to a neurodegeneration. About crack exposure, recently studies have shown that the degenerative consequences shown by the users could be due to neuronal cells necrosis and/or apoptosis in several brain areas. The real participation of AEME in those processes still remains unclear. Therefore, the aim of this study is to investigate the involvement of cocaine, AEME and the association of both on the morphologic and physiologic conditions of hippocampus neurons in vitro, seeking the process of cellular death pathways occurring in crack exposure. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
UDO, MARIANA SAYURI BERTO; DA SILVA, MARIANA AGUILERA ALENCAR; DE SOUZA PRATES, SARA; DAL'JOVEM, LEANDRO FERREIRA; DE OLIVEIRA DURO, STEPHANIE; FAIAO-FLORES, FERNANDA; GARCIA, RAPHAEL CAIO TAMBORELLI; MARIA-ENGLER, SILVYA STUCHI; MARCOURAKIS, TANIA. Anhydroecgonine methyl ester, a cocaine pyrolysis product, contributes to cocaine-induced rat primary hippocampal neuronal death in a synergistic and time-dependent manner. ARCHIVES OF TOXICOLOGY, v. 95, n. 5, . (14/08881-9, 13/20952-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
UDO, Mariana Sayuri Berto. Activation pathways characterization related to the Anhydroegconin Methyl Ester (AEME)-induced neurotoxicity in vitro.. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.

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