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Bacterial symbionts associated with stingless bee Melipona scutellaris as sources of bioactive natural products

Grant number: 14/17620-4
Support type:Scholarships in Brazil - Master
Effective date (Start): November 01, 2014
Effective date (End): July 31, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Mônica Tallarico Pupo
Grantee:Carla Menegatti
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Natural products play an important role in drug discovery. Several drugs have been discovered or developed from microbial natural products hits and leads showing a great efficiency of microorganisms to synthesize compounds with high biological potential. It is known that social insects are subjected to climate and population conditions that increase their susceptibility to parasites. Therefore, these insects have developed an evolutionary defense mechanism consisting in symbiotic association with bacteria that can biosynthesize antimicrobial products against pathogens. Based on this ecological evidence, this project proposes the study of natural products biosynthesized by symbiotic microorganisms associated to the species of stingless bee Melipona scutellaris. For this, the symbiotic microorganisms will be isolated from this species of bee and it brood cell, cultured in the laboratory for obtaining extracts, which will be fractionated for the isolation and identification of natural products. The project also aims to correlate natural products produced by the microorganisms to possible ecological and biological functions. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENEGATTI, CARLA; LOURENZON, VITOR BRUNO; RODRIGUEZ-HERNANDEZ, DIEGO; DA PAIXAO MELO, WEILAN GOMES; GOMES FERREIRA, LEONARDO LUIZ; ANDRICOPULO, ADRIANO DEFINI; DO NASCIMENTO, FABIO SANTOS; PUPO, MONICA TALLARICO. Meliponamycins: Antimicrobials from Stingless Bee-Associated Streptomyces sp.. Journal of Natural Products, v. 83, n. 3, SI, p. 610-616, MAR 27 2020. Web of Science Citations: 3.
RODRIGUEZ-HERNANDEZ, DIEGO; MELO, WEILAN G. P.; MENEGATTI, CARLA; LOURENZON, VITOR B.; DO NASCIMENTO, FABIO S.; PUPO, MONICA T. Actinobacteria associated with stingless bees biosynthesize bioactive polyketides against bacterial pathogens. NEW JOURNAL OF CHEMISTRY, v. 43, n. 25, p. 10109-10117, JUL 7 2019. Web of Science Citations: 0.
MENEGATTI, CARLA; DA PAIXAO MELO, WEILAN GOMES; CARRAO, DANIEL BLASCKE; MORAES DE OLIVEIRA, ANDERSON RODRIGO; DO NASCIMENTO, FABIO SANTOS; LOPES, NORBERTO PEPORINE; PUPO, MONICA TALLARICO. Paenibacillus polymyxa Associated with the Stingless Bee Melipona scutellaris Produces Antimicrobial Compounds against Entomopathogens. Journal of Chemical Ecology, v. 44, n. 12, p. 1158-1169, DEC 2018. Web of Science Citations: 3.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MENEGATTI, Carla. Bacterial symbionts associated with the stingless bee Melipona scutellaris as sources of bioactive natural products. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto Ribeirão Preto.

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