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Rhinella schneideri mucous gland trascriptome

Grant number: 14/15644-3
Support type:Scholarships in Brazil - Master
Effective date (Start): December 01, 2014
Effective date (End): May 31, 2016
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Eliane Candiani Arantes Braga
Grantee:Priscila Yumi Tanaka Shibao
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Natural products libraries are known as medicine molecules providers once these molecules have a high target specificity inherited from the long natural evolutionary process. Thereby, animal, plant and microorganisms' secretions are very important to biotechnological applications. However, despite the large number of molecules that can be found in those secretions, the difficulty on obtainment enough purification yield, high cost and long purification time, besides the small secretion amount provided by the studied organism, are factors that make this kind of study even harsher. Those are the reasons why omic studies are becoming an alternative to produce these toxins in a larger scale, in order to allow researches. Transcriptome, which consists on the production of cDNA libraries from the secretion or gland RNA, using the transcriptase reverse enzyme, is very important once it shows which proteins and peptides can be really found at the secretion expressed from animal DNA. Toads are animals that are still not widely studied, if we compare them with other venomous animals, mainly because of the insufficient purification yield. Thus, the mucous gland transcriptome from Rhinella schneideri poison, a toad that is widely found in Brazilian territory, has a great relevance on the elucidation and possibility to use this kind of molecules, especially because this gland produces unknown molecules. Finally, this study may provide an easier way to solve the purification yield problem besides the accomplishment to understand all the gland poison and provide the applicant a better knowledge for academic purposes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
WIEZEL, GISELE A.; SHIBAO, PRISCILA Y. T.; COLOGNA, CAMILA T.; MORANDI FILHO, ROMUALDO; UEIRA-VIEIRA, CARLOS; DE PAUW, EDWIN; QUINTON, LOIC; ARANTES, ELIANE C.. In-Depth Venome of the Brazilian Rattlesnake Crotalus durissus terrificus: An Integrative Approach Combining Its Venom Gland Transcriptome and Venom Proteome. JOURNAL OF PROTEOME RESEARCH, v. 17, n. 11, p. 3941-3958, . (15/17466-8, 13/26200-6, 11/23236-4, 17/00586-6, 14/15644-3, 15/18432-0)
BOLDRINI-FRANCA, JOHARA; COLOGNA, CAMILA TAKENO; PUCCA, MANUELA BERTO; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FERNANDO GOBBI; PINO ANJOLETTE, FERNANDO ANTONIO; CORDEIRO, FRANCIELLE ALMEIDA; WIEZEL, GISELE ADRIANO; CERNI, FELIPE AUGUSTO; PINHEIRO-JUNIOR, ERNESTO LOPES; et al. Minor snake venom proteins: Structure, function and potential applications. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 4, p. 824-838, . (14/06170-8, 11/12317-3, 11/23236-4, 15/16714-8, 12/13590-8, 13/26619-7, 14/15644-3, 12/12954-6, 13/26200-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SHIBAO, Priscila Yumi Tanaka. Rhinella schneideri mucous gland transcriptome. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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