Influence of epineprhine concentration associated with 4% articaine on the healing process of free gingival grafts

• Grant number: 14/02142-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2014
• End date: December 16, 2014
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Bella Luna Colombini Ishikiriama
• Grantee: Rayza Rodrigues Campos
• Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil

Abstract

Pain control in patients undergoing oral and maxillofacial surgery is often performed through the administration of local anesthetics and oral analgesics. Several anesthetic substances have been used for this purpose, as articaine, an amide type anesthetic, one of the most used by the dental community from various countries to present an excellent clinical efficacy. However, their intrinsic vasodilatory effects, requiers to associate these substances other with vasoconstrictor potential, in order to reduce intraoperative bleeding and, consequently, facilitate the visualization of the surgical site and give more security to the procedure. Among these substances, epinephrine, a sympathomimetic amine, is one of the most used, due to clinical safety about its use. It can be found at different concentrations in this association (1:50.000 to 1:200.000) which generate different vasoconstriction potentials and therefore control of bleeding, whereas greater concentrations may provide a lower bleeding. On the other hand, the increase in the concentration of epinephrine in order to reduce the bleeding, may compromise the fluid vessel exudation in anesthetized region in an early postoperative period (0 to 3 days) and thus, impair the initial phase of healing process in free gingival grafts, which depends on the initial phase of healing called "plasma nutrition", and may also influence the activity of cells involved in wound healing. Therefore , this research aims to evaluate the influence of epinephrine concentration (1:100.000 and 1:200.000 ) associated with articaine on the early and late healing process in bilateral surgical model of free gingival epithelial grafts. For this purpouse, 30 patients aged 18 years and requiring bilateral free gingival grafts in the region of premolars will be subjected to surgical procedures, in a crossed desing, from which data will be collected related to the action of the agent anesthetic effect of vasoconstrictor and characteristics of the healing process. A comparative analysis of the data, along with the application of proper statistical tests, provide the basis for an assessment of the influence of the concentration of epinephrine on the initial and late healing process of free gingival grafts. (AU)