Molecular characterization of Brucella canis strains circulating in Brazil

• Grant number: 14/21544-1
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Effective date (Start): September 14, 2015
• Effective date (End): September 13, 2016
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Jane Megid
• Grantee: Acácia Ferreira Vicente
• Supervisor: Virginie Mick
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Research place: Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (ANSES), France
• Associated to the scholarship: 14/00889-0 - Canine brucellosis: evaluation of genetic diversity and development of new tools for molecular typing for Brucella canis, BP.DR

Abstract

Brucellosis is a zoonosis which has a great impact on the public health and economic worldwide. Canine brucelose, often diagnosed in Brazil, has its importance in the public health given the relation animal/human. From the economic point of view causes losses in kennels due to reproductive losses and difficulty or impossibility of therapeutic. Genotyping of pathogens is essencial for monitoring transmission chains, which is required for local and global disease surveillance. This project is intended to evaluate the genetic diversity of B. canis population in the São Paulo state comparing with European ad Asian strains by MLVA-16; analyze in silico of genes supposed involved in drug resistance, virulence determinants and mobile genetic elements, and develop of a new epidemiological tool through sequencing complete genome of these strains. (AU)