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Fluoxetine thermal analytical studies

Grant number: 14/22142-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2014
Effective date (End): May 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Éder Tadeu Gomes Cavalheiro
Grantee:Bárbara Vieira Pinto
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil


Fluoxetine thermal analytical studies: Fluoxetine ((±)-N-methyl-3-phenyl-3-[(±,±,±-trifluoro-Á-tolyl)-oxy]propylamine hydrochloride is an antidepressant selective serotonin reuptake inhibitor (SSRI) for oral administration for depression, bulimia, obsessive compulsive disorder, premenstrual dysphoric disorder (PMDD), including premenstrual syndrome (PMS), irritability, and dysphoria treatment. This work aims to study fluoxetine thermal behavior and decomposition, to establish a mechanism for its thermal decomposition. Kinetic and degradation studies should also be developed.Thermogravimetric measurements will be carried out in air and nitrogen atmosphere, allowing the determination of thermal stability of the drug and decomposition steps. Simultaneously, the gases evolved during heating of the sample will be taken through a transfer line, to a spectrometer. Thermogravimetry- spectroscopy in the infrared region(TG-FTIR) will be used in the identification of gas released during fluoxetine burning, permitting to propose a mechanism for its thermal decomposition. DSC analysis at temperatures below the decomposition events may show phase transition such as melting, polymorphic transformations, among others.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, A. P. G.; PINTO, V, B.; CAVALHEIRO, E. T. G. Thermal decomposition investigation of paroxetine and sertraline. JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS, v. 136, p. 232-241, NOV 2018. Web of Science Citations: 2.
PINTO, B. V.; FERREIRA, A. P. G.; CAVALHEIRO, E. T. G. Thermal degradation mechanism for citalopram and escitalopram. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 133, n. 3, p. 1509-1518, SEP 2018. Web of Science Citations: 3.

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