"Study of the effect of the exposition to the Fipronil pesticide and the picrotoxina, on the behavior of memory in rats".

• Grant number: 14/18429-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2015
• End date: December 31, 2015
• Field of knowledge: Biological Sciences - Pharmacology - Toxicology
• Principal Investigator: Antonio Francisco Godinho
• Grantee: Ana Carolina de Oliveira Souza
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Widely used in the whole world with the function to keep healthful plantations and also the animal health, the pesticides provoke innumerable toxic effect in organisms of mammals; however, the predominant effect of this substances class is neurotoxicity. Fipronil is a pesticide of last generation that comes being widely used as much in agriculture how much in the control and prevention of ectoparasites that infest animals. Derived from phenyl pyrazole the fipronil is a chemical agent know for causing neurotoxicity, having the antagonism of gamma-amino butyric acid (GABA) as their main mechanism of toxic action. Physiologically, it is known that GABA is involved in processes related to the formation and consolidation of memory. Picrotoxin, a toxic substance extracted of the plant Anamirta cocculus, popularly known as climber anamirta, acts as antagonist on the GABA receptor on similar way to the fipronil. The goal of this project is to study experimentally in rats the effects of exposure to the fipronil pesticide together with picrotoxin, evaluating the responses of animals in relation to the memory behavior.

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

GODINHO, ANTONIO FRANCISCO; OLIVEIRA SOUZA, ANA CAROLINA DE; CARVALHO, CAIO CRISTOVAO; HORTA, DANIEL FRANCA; DE FRAIA, DANIEL; ANSELMO, FABIO; CHAGURI, JOAO LEANDRO; FARIA, CAIQUE APARECIDO. Memory impairment due to fipronil pesticide exposure occurs at the GABA(A) receptor level, in rats. Physiology & Behavior, v. 165, p. 28-34, OCT 15 2016. (14/18433-3, 14/18429-6)