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Gene expression profiling of HOX genes family in a panel of 70 cancer cell lines

Grant number: 14/20379-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2014
Effective date (End): November 30, 2016
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Wilson Araújo da Silva Junior
Grantee:Natália Volgarine Scaraboto
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/08135-2 - CTC - Center for Cell-Based Therapy, AP.CEPID

Abstract

Hox genes are a subset of the Homeobox family, which are characterized by high degree of conservation among fungi, plants and animals. In mammals, Hox genes are subdivided into four genetic groups or clusters: HOXA, HOXB, HOXC, and HOXD, located on chromosomes 2, 7, 17 and 12, respectively. To date 39 HOX genes have been identified, which acts in embryonic development as regulating biological processes as proliferation, differentiation, migration, angiogenesis and apoptosis. These processes are reactivated during carcinogenesis and regulated by genetic programs that include the Hox genes. Recent studies indicate that Hox genes may play an important role in several types of cancer1,2,3,4,5. These studies join others that use tumor cell lines to characterize the function of genes during cancer development6. In this sense, this project aims to assess the expression profile of Hox genes into a tumor cell lines panel to identify which strains would be more suitable for functional studies of Hox genes.