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Study of intestinal Th17 response role in obesity-induced type 2 diabetes

Grant number: 14/21020-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): December 01, 2014
Effective date (End): February 29, 2016
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal Investigator:Daniela Carlos Sartori
Grantee:Malena Martínez Pérez
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:12/10395-0 - Role of NLRs receptors in immunoregulation mechanisms of the type 1 and 2 diabetes: identification of potential therapeutic targets, AP.JP


Type 2 diabetes mellitus (T2DM)is a chronic inflammatory disease characterized by insulin resistance and glucose intolerance resulting in dysfunction, destruction of beta cells or both. One of the main causes of T2DM is obesity, which correlates with the establishment of an inflammatory process and the activation of innate immunity cells, called metabolic inflammation. It is known that intestinal homeostasis is determined by a balance between Treg and Th17 lymphocytes, which is induced in the presence of IL-1beta and IL-23 in response to components of the intestinal microbiota. Furthermore, it was shown that Th17 lymphocytes in the intestine are essential for controlling the colonization and bacterial translocation by producing antimicrobial peptides, and cytokines such as IL-17 and IL-22. Some studies have reported that obese and diabetic individuals show changes in the proportion and configuration of bacteria in the intestinal microbiota called intestinal dysbiosis. Such changes in the microbiome can result in disruption of the intestinal barrier, increased permeability, endotoxemia and metabolic inflammation. However, there are no reports on the importance of cytokines produced by Th17 lymphocytes in the control of intestinal dysbiosis and its implication in the development of obesity-induced T2DM.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREZ, MALENA M.; MARTINS, LARISSA M. S.; DIAS, MURILO S.; PEREIRA, CAMILA A.; LEITE, JEFFERSON A.; GONCALVES, ENRICO C. S.; DE ALMEIDA, PAULA Z.; DE FREITAS, EMANUELLE N.; TOSTES, RITA C.; RAMOS, SIMONE G.; et al. Interleukin-17/interleukin-17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high-fat diet-induced metabolic syndrome model. IMMUNOLOGY, v. 156, n. 4, p. 339-355, . (12/10395-0, 13/08216-2, 14/21020-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PÉREZ, Malena Martínez. Immunomodulator role of intestinal interleukin-17 in inflammatory and metabolic responses in type 2 diabetes. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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