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Automated quantification of transverse relaxation time: identification of iron deposits in the brain

Grant number: 14/19786-7
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2015
Effective date (End): October 31, 2017
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Marcondes Cavalcante Franca Junior
Grantee:Thiago Junqueira Ribeiro de Rezende
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):15/09793-9 - Multimodal atlas-based analyses to characterize structural damage in Friedreich's ataxia, BE.EP.DR

Abstract

Brain iron accumulation plays a key role in several neurodegenerative disorders, such as Parkinson's disease, Multiple Sclerosis and Friedreich ataxia. In this scenario, methods that enable in vivo identification and quantification of such deposits are extremely helpful in neurological practice. There are different MRI-based strategies to estimate iron deposition. T2*/T2 relaxometry is the most widely used technique and presents significant correlation with histological measurement of iron. However, a major limitation of relaxometry is that is not automatized and ROI-based.The main objective of this study is to develop a semi-automatic method to quantify the transverse relaxation times in a voxelwise approach. Afterwards, we will perform a clinical application of this method in patients with Friedreich ataxia. Our ultimate objective will be the search for new biomarkers to help both in the clinical follow-up and in the comprehension of neurodegenerative mechanisms rated to Friedreich ataxia. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
REZENDE, T. J. R.; MARTINEZ, A. R. M.; FABER, I.; GIROTTO TAKAZAKI, K. A.; MARTINS, M. P.; DE LIMA, F. D.; LOPES-CENDES, I.; CENDES, F.; FRANCA, M. C. Developmental and neurodegenerative damage in Friedreich's ataxia. EUROPEAN JOURNAL OF NEUROLOGY, v. 26, n. 3, p. 483-489, MAR 2019. Web of Science Citations: 2.
RIBEIRO REZENDE, THIAGO JUNQUEIRA; RIBEIRO DE PAIVA, JEAN LEVI; MURO MARTINEZ, ALBERTO ROLIM; LOPES-CENDES, ISCIA; PEDROSO, JOSE LUIZ; POVOAS BARSOTTINI, ORLANDO GRAZIANI; CENDES, FERNANDO; FRANCA, JR., MARCONDES C. Structural signature of SCA3: From presymptomatic to late disease stages. ANNALS OF NEUROLOGY, v. 84, n. 3, p. 401-408, SEP 2018. Web of Science Citations: 8.
MARTINS JUNIOR, CARLOS ROBERTO; DE BORBA, FABRICIO CASTRO; MURO MARTINEZ, ALBERTO ROLIM; RIBEIRO DE REZENDE, THIAGO JUNQUEIRA; CENDES, ISCIA LOPES; PEDROSO, JOSE LUIZ; POVOAS BARSOTTINI, ORLANDO GRAZIANI; FRANCA JUNIOR, MARCONDES CAVALCANTE. Twenty-five years since the identification of the first SCA gene: history, clinical features and perspectives for SCA1. Arquivos de Neuro-Psiquiatria, v. 76, n. 8, p. 555-562, AUG 2018. Web of Science Citations: 2.
MARTINEZ, ALBERTO R. M.; CASSEB, RAPHAEL F.; MARTINS, JR., CARLOS R.; NUCCI, ANAMARLI; FRANCA, JR., MARCONDES C. Sensory neuronopathy heralding human T cell lymphotropic virus type I myelopathy. JOURNAL OF NEUROVIROLOGY, v. 24, n. 3, p. 369-371, JUN 2018. Web of Science Citations: 0.
ALBERTO R. M. MARTINEZ; CARLOS ROBERTO MARTINS JR; LUCAS N. DE RESENDE; TÂNIA A. M. O. CARDOSO; FABIANO REIS; MARCONDES C. FRANÇA JR. Lemierre's syndrome leading to cerebral venous thrombosis. Arquivos de Neuro-Psiquiatria, v. 76, n. 5, p. -, Maio 2018.
REZENDE, THIAGO JUNQUEIRA R.; MARTINEZ, ALBERTO ROLIM M.; FABER, INGRID; GIROTTO, KAREN; PEDROSO, JOSE LUIZ; BARSOTTINI, ORLANDO G.; LOPES-CENDES, ISCIA; CENDES, FERNANDO; FARIA, ANDREIA V.; FRANCA, MARCONDES C. Structural signature of classical versus late-onset friedreich's ataxia by Multimodality brain MRI. Human Brain Mapping, v. 38, n. 8, p. 4157-4168, AUG 2017. Web of Science Citations: 4.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
REZENDE, Thiago Junqueira Ribeiro de. Neuroimaging in Friedreich's ataxia : new approaches and clinical aplication. 2017. Doctoral Thesis - Universidade Estadual de Campinas, Faculdade de Ciências Médicas.

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