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Mechanisms that regulate the processing of IL-1a, IL-1b and their role during experimental Trypanosoma Cruzi infection

Grant number: 14/25585-4
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): February 28, 2015
Effective date (End): February 27, 2016
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:João Santana da Silva
Grantee:Grace Kelly da Silva
Supervisor abroad: Douglas Taylor Golenbock
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Local de pesquisa : University of Massachusetts Medical School (UMMS), United States  
Associated to the scholarship:13/00579-9 - Role of inflammasomes and IL-1 in experimental infection by Trypanosoma cruzi, BP.PD

Abstract

The parasite Trypanosome cruzi is agent causative of Chagas disease. This pathogen causes robust innate immune responses in immunocompetent hosts, resulting in the recruitment of mononuclear cells to the heart. The pattern recognition receptors (PRRs), including TLR-2, -4, -7, and -9, as well as the cytosolic receptor Nod1 recognize pattern molecular pathogen associated to T. cruzi and trigger stronger immune response. Recently, we showed that inflammasomes and IL-1R are necessary for efficient control of this parasite. As both, IL-1a and IL-1b signal via the IL-1R, our goal is to elucidate the immune responses in mice lacking either of these cytokines, as to understand the mechanisms necessary to processing and release of IL-1a and IL-1b. (AU)