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Influence of gender in nasal mucociliary clearance of smokers

Grant number: 14/11970-3
Support type:Scholarships in Brazil - Master
Effective date (Start): January 01, 2015
Effective date (End): May 31, 2016
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Ercy Mara Cipulo Ramos
Grantee:Juliana Souza Uzeloto
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
Associated scholarship(s):15/13353-4 - Clinical practice guidelines in physiotherapy for the management of chronic respiratory diseases: a critical appraisal, BE.EP.MS


Introduction: The main defense mechanism of the respiratory system is the mucociliary clearance, which has a function of eliminate harmful particles. It is known that internal and external factors alter this transportability, smoking is among them and is known to have a negative effect. Considering the influence of gender, non-smokers women show better mucociliary clearance when compared to men. However, there is evidence that when women are smokers they show bigger susceptibility for diverse diseases, in relation to the other gender. Nevertheless, there aren't studies that show whether there is difference nasal mucociliary clearance behavior among men and women who are smokers. Aim: Evaluate the influence of gender in nasal mucociliary clearance of smokers, as well as co-relate saccharin transport time by the amount of smoking load of these subjects. Methods: For that, a total of 132 subjects, being 66 smokers and 66 non-smokers, will be assessed. The protocol will be performed in two days for both groups. On the first day, the first evaluation and spirometry to assess the lung function will be done. On the second day, the saccharin transport time test will be done. Statistical analysis: In order to analyze the data the statistical software Graphpad Prism® will be used. The normality of data distribution will be evaluated by using the test Kolmogorov-Smirnov, and the description of the data will be shown as mean ± standard deviation, except for variables with abnormal distribution, which will be described as median (interquartile range 25-75). In order to compare the groups, non-paired t test will be used for normal data and, for abnormal data, the Mann-Withney test will be used. The level of significance will be p<0.05. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JULIANA SOUZA UZELOTO; DIONEI RAMOS; ANA PAULA C.F. FREIRE; DIEGO G.D. CHRISTOFARO; ERCY MARA C. RAMOS. Nasal mucociliary transportability of male and female smokers. Brazilian Journal of Otorhinolaryngology, v. 84, n. 3, p. -, Jun. 2018.
UZELOTO, JULIANA SOUZA; RAMOS, DIONEI; FREIRE, ANA PAULA C. F.; CHRISTOFARO, DIEGO G. D.; RAMOS, ERCY MARA C. Nasal mucociliary transportability of male and female smokers. Brazilian Journal of Otorhinolaryngology, v. 84, n. 3, p. 311-317, MAY-JUN 2018. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
UZELOTO, Juliana Souza. Avaliação da transportabilidade mucociliar nasal de homens e mulheres tabagistas e qualidade de diretrizes de prática clínica para doenças respiratórias crônicas. 2016. 90 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências e Tecnologia..

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