Conjugation of superparamagnetic nanoparticles of iron oxide and curcumin: associa...
| Grant number: | 14/20228-9 |
| Support type: | Scholarships in Brazil - Scientific Initiation |
| Effective date (Start): | January 01, 2015 |
| Effective date (End): | December 31, 2015 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry |
| Principal Investigator: | Paula Silvia Haddad Ferreira |
| Grantee: | Guilherme Ferreira Lemos Pereira |
| Home Institution: | Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil |
Abstract Nanoparticles exhibit physical and chemical properties that differ so much from their bulk materials. Quantum size and surface effects, dependence between electronic structure and nanoparticle size, high value of the surface area and volume ratio are some characteristics of the different behavior of nanoparticulated systems. In this context, this project is focused on the synthesis, characterization and colloidal stabilty investigation of Fe3O4 nanoparticles. To this end, two synthetic routes are proposed: First, by coprecipitation of Fe salts and second by the method of thermodecomposition of organometallic compounds such as [Fe(Acac)3] with high control of size, morphology and composition. The control of these characteristics allows the adjustment of their magnetic properties such as saturation magnetization and superparamagnetism. In addition, the study of the hydrophilic/hydrophobic balance on the surface of the nanoparticles through the gradual change of hydrophobic ligands, such as oleic acid present on the surface of the nanoparticles by hydrophilic molecules such as dimercaptsuccinic acid (DMSA) and mercaptosuccinic acid (MSA) is proposed. We intend to optimize the structural, morphological characteristics and the colloidal stability of these systems for potential application as magnetic refrigerators. | |