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Correlation between early and late lymphatic changes after breast cancer surgery and risk for developing lymphedema

Grant number: 14/14190-9
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): January 01, 2015
Effective date (End): December 31, 2016
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Luís Otávio Zanatta Sarian
Grantee:Mariana Maia de Oliveira Sunemi
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Lymphedema of ipsilateral mastectomy has an incidence between 24 and 49% and may be present immediately after surgery or years after treatment, promoting substantial functional and psychological damage. Among the risk factors for its development are axillary dissection, radiotherapy, level of lymph nodes dissection, extent of surgical technique among others. The etiology and pathophysiology that results in lymphatic failure are not clearly understood. A previous study observed significant changes in lymphoscintigraphy pre -and postoperative of mastectomy women, demonstrating the existence of functional differences in the lymphatic system of the upper limb. Objective: To study the relationship between lymphatic compensation present in the early postoperative period (60 days) and late (two years) and the development of lymphedema. Subjects and methods: A prospective cohort study with women undergoing radical surgery for breast cancer at the Center for Integral Attention to Women's State University of Campinas, Brazil for at least 2 years. The sociodemographic and clinical data and physical assessment - perimetry and palpation of the upper limbs and shoulder goniometry - will be collected at the outpatient physiotherapy. Lymphatic change will be assessed through the lymphoscintigraphy performed at the Hospital of Unicamp. All data will be obtained through the reports examining, which follows the standards of collecting data sheet. The data will be evaluated descriptively, the categorical variables will be calculated by the absolute (n) and relative frequencies (%) and continuous variables by mean, median and standard deviation. Odds ratio will be calculated for analysis of categorical variables. The significance level is 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FREIRE DE OLIVEIRA, MARIANA MAIA; COSTA GURGEL, MARIA SALETE; AMORIM, BARBARA JUAREZ; RAMOS, CELSO DARIO; DERCHAIN, SOPHIE; FURLAN-SANTOS, NATACHIE; DOS SANTOS, CESAR CABELLO; SARIAN, LUIS OTAVIO. Long term effects of manual lymphatic drainage and active exercises on physical morbidities, lymphoscintigraphy parameters and lymphedema formation in patients operated due to breast cancer: A clinical trial. PLoS One, v. 13, n. 1, . (09/14864-1, 14/14190-9)

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