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Evaluation of skin permeation of bromelain using in vitro diffusion experiment

Grant number: 14/26304-9
Support Opportunities:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): February 01, 2015
Effective date (End): April 30, 2015
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Priscila Gava Mazzola
Grantee:Janaína Artem Ataide
Supervisor: Xiaochen Gu
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: University of Manitoba, Canada  
Associated to the scholarship:11/23076-7 - Bromelain extraction from pineapple residues using ethanol precipitation and its application in polymeric hydrogel, BP.IC


Bromelain is a set of proteolytic enzymes found in various parts such as bark, stem, leaves and fruit of pineapple (Ananas comosus), and other species of the family Bromeliaceae. Due to its fibrinolytic, anti-inflammatory and healing properties, it is used in treating diseases related to blood clotting, angina, indigestion and respiratory problems. Hydrogels are tridimensional networks, capable of retain small molecules, such as proteins and drugs, in their structure. Hydrogels show various functional properties proposed to biomedical and pharmaceutical applications. Among those applications, hydrogel use as a drug delivery system is at the most interest at scientific researches. Studies showed that hydrogels are excellent candidates for biomolecules encapsulation, such as peptides and proteins, providing a controlled and sustained drug release system.Bacterial nanocellulose, as well as hydrogels, presents properties that make its use on biomedical and pharmaceutical fields a quite interesting. Due to its production process, bacterial nanocellulose is considered a biocompatible material. Its nanofibrilar structure is an ideal matrix for medical devices, as an aid in healing skin lesions or in tissue engineering, assisting cell regeneration. The incorporation of bioproducts, with biological properties, in hydrogels and bacterial nanocellulose has an extended application on biotechnological field, specially, on microbiology, medical-pharmaceutical (through skin lesions recuperation), chemical, cosmetic, nutrition and others. Therefore, studies aiming bromelain application in hydrogels and nanocellulose membranes are highly promising from a scientific and technologic standpoint. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ATAIDE, JANAINA ARTEM; CEFALI, LETICIA CARAMORI; REBELO, MARCIA DE ARAUJO; SPIR, LIVIA GENOVEZ; TAMBOURGI, ELIAS BASILE; JOZALA, ANGELA FAUSTINO; CHAUD, MARCO VINICIUS; SILVEIRA, EDGAR; GU, XIAOCHEN; MAZZOLA, PRISCILA GAVA. Bromelain Loading and Release from a Hydrogel Formulated Using Alginate and Arabic Gum. Planta Medica, v. 83, n. 10, p. 870-876, . (11/23076-7, 14/26304-9)

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