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Vector competence of Nyssomyia intermedia and Nyssomyia neivai for Leishmania (Viannia) braziliensis

Grant number: 14/19291-8
Support type:Scholarships in Brazil - Master
Effective date (Start): January 01, 2015
Effective date (End): December 31, 2016
Field of knowledge:Biological Sciences - Parasitology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Mauro Toledo Marrelli
Grantee:Cecilia de Oliveira Lavitschka
Home Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Leishmaniasis is a disease caused by protozoa of the genus Leishmania and can manifest itself in two main types: cutaneous leishmaniasis and visceral leishmaniasis. American Cutaneous Leishmaniasis (ACL) causes large public health impact due to deformities occasioned in the patient causing psychological, social, and economic problems. The species of Leishmania with wider distribution and accounts for the largest number of cases of ACL in Brazil is the Leishmania braziliensis this protozoa is transmitted through the bite of sandflies (Diptera: Psychodidae: Phlebotominae) and, among the species involved in the transmission stand out Nyssomyia intermedia and Nyssomyia neivai, in the Southeast of the country. Both species are anthropophilic and present in locations with occurrence of autochthonous cases of ACL have been found naturally infected by Leishmania sp and show experimentally susceptibility to infection by L. braziliensis. Objective: To experimentally evaluate the vector competence of N. intermedia and N. neivai for L. braziliensis. Methodology: The first generation will be obtained from specimens captured in the municipality of Iporanga - SP. The infection experiments will be performed by feeding female F1 in hamsters infected with L. braziliensis presenting lesions on the extremities of his legs. After the period of extrinsic incubation will be challenged to feed themselves in hamsters clean, which will be followed for six months. Expected results: It is expected to demonstrate the competence of these two species of sand flies in the transmission of L. braziliensis and contribute to knowledge of the role of these sand flies in the epidemiologyof ACL. (AU)

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LAVITSCHKA, Cecilia de Oliveira. Vector competence of Nyssomyia intermedia and Nyssomyia neivai (Diptera, Psychodidae, Phlebotominae) for Leishmania (Viannia) braziliensis. 2017. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Medicina Tropical de São Paulo São Paulo.

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