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Psychopharmacological investigation on comorbidity influence between chronic neuropathic pain and depression

Grant number: 14/26228-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2015
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal Investigator:Renato Leonardo de Freitas
Grantee:Rafael Braghetto Malvestio
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/12916-0 - Role of endocannabinoid, glutamatergic and endovanilloid systems of medial prefrontal cortex in neuropathic pain model and investigation of neurological disorders and chronic pain comorbidity, AP.JP


The "International Association for the Study of Pain" (IASP) showed that about one in five people suffer from chronic pain worldwide. The effects on quality of life are overwhelming. Chronic neuropathic pain (NP) is one of the major health problems, which it can affect more than 20% of adults. Patients with NP are also affected with problems like insomnia (60%), difficulty concentrating (36%), depression (33%) and anxiety (27%). Furthermore, the NP and their comorbidity with depression are a challenging disease with respect to their treatment, thereby necessitating the use of experimental animal models for the elucidation of its underlying psychopharmacological mechanisms and the development of new therapeutic strategies to the. Considering the comorbidity between chronic pain and depression and the involvement of cortical areas as the medial prefrontal cortex (CLPC) in its modulation, animals with neuropathic pain (NP) induced by chronic constriction injury of the sciatic nerve (CCI) will be submitted the experimental predictive test for depression, the forced swimming test. Von Frey will be the nociceptive test will be performed, in which the nociceptive response after the forced swimming test also will be evaluated on the 21th day after the CCI. The pharmacological study will investigate the involvement of the glutamatergic, endovanniloid and endocannabinoid systems, as well as, NMDA receptors, TRPV1 channels and CB1 receptors of MPFC through the microinjection of agonist and antagonist at crescents concentrations, evaluating the influence of pretreatments of MPFC on the comorbidity between chronic neuropathic pain with stress and depression in an experimental model of chronic constriction DN induced by nervus ischiadicus in rats.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MALVESTIO, R. B.; MEDEIROS, P.; NEGRINI-FERRARI, S. E.; OLIVEIRA-SILVA, M.; MEDEIROS, A. C.; PADOVAN, C. M.; LUONGO, L.; MAIONE, S.; COIMBRA, N. C.; DE FREITAS, R. L.. Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT1A and CB1 receptors. Brain Research Bulletin, v. 174, p. 323-338, . (14/16720-5, 12/25167-2, 17/13560-5, 14/26228-0, 09/17258-5, 14/07902-2)

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