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Structural and functional brain changes in psychotic disorders

Grant number: 14/23525-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2015
Effective date (End): December 31, 2015
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal researcher:Cristina Marta Del-Ben
Grantee:Carlo Rondinoni
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:12/05178-0 - Schizophrenia and other psychotic disorders: social and biological determinants, AP.TEM

Abstract

This proposal is part of a multicenter study, the European Network of National Networks Studying Schizophrenia Gene-Environment Interactions (EU-GEI; http://www.eu-gei.eu/), an international consortium that aims to investigate etiology, mechanisms and prognosis of Schizophrenia and other psychosis (SOP). This proposal aims to estimate the incidence of SOP in the region of Ribeirão Preto-SP, Brazil, and to investigate possible interactions between social and biological factors in the occurrence of mental disorders. Specifically the subproject Structural and Functional Brain abnormalities in Psychotic Disorders aimed to investigate: a) anatomic changes in the brain of individuals with EOP, compared with healthy controls and with individuals at risk of EOP (healthy siblings), b) pre-morbid and clinical factors associated with anatomical changes in the brain of individuals with EOP c) associations between genetic variants and anatomical changes in the brain of individuals with EOP, using Genome Wide Associations (GWA).

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