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Analysis of immunonotulation induced by cigarette smoke in two murine models of chronic allergic pulmonary inflammation

Grant number: 14/12398-1
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2015
Effective date (End): June 30, 2017
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal Investigator:Milton de Arruda Martins
Grantee:Thayse Regina Bruggemann
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):15/26048-5 - Analysis of dendritic cell and T cell pathway in a murine model of chronic pulmonary allergic inflammation with exposition to cigarette smoke, BE.EP.DD


Asthma affects approximately 300 million people worldwide and is the leading cause of hospitalization in children in developed countries. This disease is incurable and often refractory to treatment in a significant number of patients. It has been the subject of research in attempt to understand its mechanisms. The prevalence of smoking among asthmatic patients is similar to the general population. Smokers with asthma have an accelerated decline in lung function, more severe asthma symptoms, increased number of hospitalizations and increase the risk of mortality after hospital admission for an episode of potentially fatal asthma compared with asthmatic nonsmokers. The impact of cigarette smoke on asthma remains controversial both clinically and experimentally. The objective of this study is to evaluate the inflammatory profile in immunoregulation caused by coexposition to cigarette smoke on pulmonary allergic inflammation induced previously ovalbumin (OVA). The effect of cigarette smoke on allergic pulmonary inflammation induced by OVA will be assessed by bronchial responsiveness, lung remodeling in pulmonary and systemic inflammatory cells and production of antigen-specific antibodies (IgG1, IgG2a and IgE) profile as well as the production of and modulating inflammatory cytokines. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BRUGGEMANN, THAYSE REGINA; FERNANDES, PAULA; OLIVEIRA, LUANA DE MENDONCA; SATO, MARIA NOTOMI; MARTINS, MLTON DE ARRUDA; ARANTES-COSTA, FERNANDA MAGALHAES. Cigarette Smoke Increases CD8 alpha(+) Dendritic Cells in an Ovalbumin-Induced Airway Inflammation. FRONTIERS IN IMMUNOLOGY, v. 8, . (14/12398-1, 15/26048-5, 14/21395-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BRUGGEMANN, Thayse Regina. Profile and to analyze the role of dendritic cells on the immunomodulation caused by exposure to cigarette smoke in ovalbumin (OVA)-induced pulmonary allergic inflammation. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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